Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice
Kudryashov N. V., Kalinina T. S., Shimshirt A. A., Korolev A. O., Volkova A. V., Voronina T. A.
Behavioural Pharmacology
Vol.29, Issue4, P. 375-378
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1097/FBP.0000000000000359
Аннотация:
The antidepressant-like effect of fluoxetine (20 mg/kg i.p.) has been assessed using the forced swimming test (FST) in IRC (CD-1) mice exposed or not to a pretest session of different duration (5 or 20 min). The influence of the mitochondrial translocator protein (TSPO) activity on the antidepressant-like effect of fluoxetine (20 mg/kg i.p.) in the FST was also studied. The antidepressant-like effect of fluoxetine was observed only in mice subjected to a 5-min pretest session 24 h before the FST. The TSPO antagonist PK11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; 1 or 3 mg/kg i.p.] inhibited the antidepressant activity of fluoxetine in the FST. In the present study, fluoxetine or PK11195 was administered for a short duration. We suppose that the functional activity of TSPO may depend on a pretest session and that using this procedure is necessary to detect antidepressant activity of fluoxetine-like drugs. Copyright © 2018 Wolters Kluwer Health, Inc. A
Ключевые слова:
antidepressants; fluoxetine; forced swimming test; mouse
carrier protein; fluoxetine; mitochondrial protein; n sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide; sodium chloride; antidepressant agent; fluoxetine; isoquinoline derivative; mitochondrial trifunctional protein; n sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide; serotonin uptake inhibitor; animal experiment; antidepressant activity; Article; controlled study; drug inhibition; forced swim test; immobility; male; mouse; nonhuman; post hoc analysis; treatment duration; animal; depression; disease model; drug effect; Institute for Cancer Research mouse; mental stress; metabolism; motor activity; physiology; signal transduction; swimming; Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Fluoxetine; Isoquinolines; Male; Mice; Mice, Inbred ICR; Mitochondrial Trifunctional Protein; Motor Activity; Serotonin Uptake Inhibitors; Signal Transduction; Stress, Psychological; Swimming
Язык текста: Английский
ISSN: 1473-5849
Kudryashov N. V. Nikita Viktorovich 1989-
Kalinina T. S.
Shimshirt A. A.
Korolev A. O.
Volkova A. V.
Voronina T. A.
Кудряшов Н. В. Никита Викторович 1989-
Калинина Т. С.
Шимширт А. А.
Королев А. О.
Волкова А. В.
Воронина Т. А.
Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice
Текст визуальный непосредственный
Behavioural Pharmacology
Lippincott Williams & Wilkins
Vol.29, Issue4 P. 375-378
2018
Статья
antidepressants fluoxetine forced swimming test mouse
carrier protein fluoxetine mitochondrial protein n sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide sodium chloride antidepressant agent fluoxetine isoquinoline derivative mitochondrial trifunctional protein n sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide serotonin uptake inhibitor animal experiment antidepressant activity Article controlled study drug inhibition forced swim test immobility male mouse nonhuman post hoc analysis treatment duration animal depression disease model drug effect Institute for Cancer Research mouse mental stress metabolism motor activity physiology signal transduction swimming Animals Antidepressive Agents Depression Depressive Disorder Disease Models, Animal Fluoxetine Isoquinolines Male Mice Mice, Inbred ICR Mitochondrial Trifunctional Protein Motor Activity Serotonin Uptake Inhibitors Signal Transduction Stress, Psychological Swimming
The antidepressant-like effect of fluoxetine (20 mg/kg i.p.) has been assessed using the forced swimming test (FST) in IRC (CD-1) mice exposed or not to a pretest session of different duration (5 or 20 min). The influence of the mitochondrial translocator protein (TSPO) activity on the antidepressant-like effect of fluoxetine (20 mg/kg i.p.) in the FST was also studied. The antidepressant-like effect of fluoxetine was observed only in mice subjected to a 5-min pretest session 24 h before the FST. The TSPO antagonist PK11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; 1 or 3 mg/kg i.p.] inhibited the antidepressant activity of fluoxetine in the FST. In the present study, fluoxetine or PK11195 was administered for a short duration. We suppose that the functional activity of TSPO may depend on a pretest session and that using this procedure is necessary to detect antidepressant activity of fluoxetine-like drugs. Copyright © 2018 Wolters Kluwer Health, Inc. A