Next-Generation of Allergen-Specific Immunotherapies: Molecular Approaches
Curin M., Khaitov M., Karaulov A. V., Namazova-Baranova L. S., Campana R., Garib V., Valenta R.
Current Allergy and Asthma Reports
Vol.18, Issue7, Num.39
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.1007/s11882-018-0790-x
Аннотация:
Purpose of Review: The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy. Recent Findings: AIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the therapeutic antigen preparations which are derived from natural allergen sources. The field of allergy diagnosis is currently undergoing a dramatic improvement through the use of molecular testing with defined, mainly recombinant allergens which allows high-resolution diagnosis. Several studies demonstrate that molecular testing in early childhood can predict the develo
Ключевые слова:
Allergen; Allergen-specific immunotherapy (AIT); Allergen-specific prevention of allergy; Allergy; Hypoallergens; Molecular allergology; Peptide-carrier vaccine; Peptides; Recombinant allergen
allergen; DNA vaccine; epitope; peptide; recombinant allergen; RNA vaccine; vaccine; allergen; allergy; antigen presenting cell; B lymphocyte; dendritic cell; desensitization; drug indication; eosinophil; good manufacturing practice; human; immunological tolerance; mast cell; nonhuman; Review; T lymphocyte; vaccination; child; desensitization; hypersensitivity; immunology; molecular medicine; primary prevention; procedures; Allergens; Child; Desensitization, Immunologic; Humans; Hypersensitivity; Molecular Medicine; Primary Prevention
Язык текста: Английский
ISSN: 1534-6315
Curin M.
Khaitov M.
Karaulov A. V. Aleksandr Viktorovich 1953-
Namazova-Baranova L. S. Lejla Sejmurovna 1963-
Campana R.
Garib V.
Valenta R. Rudol`f 1963-
Cурин М.
Хаитов М.
Караулов А. В. Александр Викторович 1953-
Намазова-Баранова Л. С. Лейла Сеймуровна 1963-
Cампана Р.
Гариб В.
Валента Р. Рудольф 1963-
Next-Generation of Allergen-Specific Immunotherapies: Molecular Approaches
Текст визуальный непосредственный
Current Allergy and Asthma Reports
Current Science Inc.
Vol.18, Issue7 Num.39
2018
Обзор
Allergen Allergen-specific immunotherapy (AIT) Allergen-specific prevention of allergy Allergy Hypoallergens Molecular allergology Peptide-carrier vaccine Peptides Recombinant allergen
allergen DNA vaccine epitope peptide recombinant allergen RNA vaccine vaccine allergen allergy antigen presenting cell B lymphocyte dendritic cell desensitization drug indication eosinophil good manufacturing practice human immunological tolerance mast cell nonhuman Review T lymphocyte vaccination child desensitization hypersensitivity immunology molecular medicine primary prevention procedures Allergens Child Desensitization, Immunologic Humans Hypersensitivity Molecular Medicine Primary Prevention
Purpose of Review: The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy. Recent Findings: AIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the therapeutic antigen preparations which are derived from natural allergen sources. The field of allergy diagnosis is currently undergoing a dramatic improvement through the use of molecular testing with defined, mainly recombinant allergens which allows high-resolution diagnosis. Several studies demonstrate that molecular testing in early childhood can predict the develo