Comparison of training and detraining on redox state of rats: Gender specific differences
Bradic J., Ruzicic R. D., Jeremic J., Petkovic A., Stojic I., Nikolic T., Zivkovic V., Srejovic I., Radovanovic D., Yakovlevich V.
General Physiology and Biophysics
Vol.37, Issue3, P. 285-297
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Given the fact that oxidative stress response induced by training/detraining has still not been clarified and may be influenced by gender, the aim of our investigation was to compare the effects of swimming training and detraining on oxidative and antioxidative parameters in rats, with a special focus on sex differences. Wistar albino rats (n = 64) were divided into 4 groups: control, trained group, groups exposed to 2 and 4 weeks of detraining. Each group included two subgroups: males and females. After sacrificing, hearts were isolated and retrogradely perfused according to Langendorff technique. Levels of superoxide anion radical, hydrogen peroxide, nitrites and thiobarbituric acid reactive substances were measured in plasma and coronary venous effluent, while reduced glutathione, activities of superoxide dismutase and catalase were measured in erythrocytes. Our results indicate that swimming training doesn't promote oxidative damage, nor act protectively within the heart. However,
Ключевые слова:
catalase; glutathione; hydrogen peroxide; nitrite; superoxide; superoxide dismutase; thiobarbituric acid reactive substance; antioxidant; biological marker; glutathione; hydrogen peroxide; superoxide; thiobarbituric acid reactive substance; animal experiment; Article; comparative study; controlled study; coronary artery blood flow; enzyme activity; erythrocyte; exercise; female; lipid peroxidation; male; nonhuman; oxidation reduction state; oxidative stress; rat; sex difference; swimming; training; animal; animal experiment; cardiac muscle; catalepsy; metabolism; oxidation reduction reaction; sexual characteristics; swimming; Wistar rat; Animals; Antioxidants; Biomarkers; Catalepsy; Female; Glutathione; Hydrogen Peroxide; Male; Myocardium; Oxidation-Reduction; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Wistar; Sex Characteristics; Superoxides; Swimming; Thiobarbituric Acid Reactive Substances
Язык текста: Английский
ISSN: 1338-4325
Bradic J.
Ruzicic R. D.
Jeremic J.
Petkovic A.
Stojic I.
Nikolic T.
Zivkovic V.
Srejovic I.
Radovanovic D.
Yakovlevich V. Vladimir 1971-
Брадиc Й.
Рузиcиc Р. Д.
Йеремиc Й.
Петковиc А.
Стойиc И.
Николиc Т.
Зивковиc В.
Срейовиc И.
Радовановиc Д.
Яковлевич В. Владимир 1971-
Comparison of training and detraining on redox state of rats: Gender specific differences
Текст визуальный непосредственный
General Physiology and Biophysics
Slovenska Akademia Vied
Vol.37, Issue3 P. 285-297
2018
Статья
catalase glutathione hydrogen peroxide nitrite superoxide superoxide dismutase thiobarbituric acid reactive substance antioxidant biological marker glutathione hydrogen peroxide superoxide thiobarbituric acid reactive substance animal experiment Article comparative study controlled study coronary artery blood flow enzyme activity erythrocyte exercise female lipid peroxidation male nonhuman oxidation reduction state oxidative stress rat sex difference swimming training animal animal experiment cardiac muscle catalepsy metabolism oxidation reduction reaction sexual characteristics swimming Wistar rat Animals Antioxidants Biomarkers Catalepsy Female Glutathione Hydrogen Peroxide Male Myocardium Oxidation-Reduction Oxidative Stress Physical Conditioning, Animal Rats Rats, Wistar Sex Characteristics Superoxides Swimming Thiobarbituric Acid Reactive Substances
Given the fact that oxidative stress response induced by training/detraining has still not been clarified and may be influenced by gender, the aim of our investigation was to compare the effects of swimming training and detraining on oxidative and antioxidative parameters in rats, with a special focus on sex differences. Wistar albino rats (n = 64) were divided into 4 groups: control, trained group, groups exposed to 2 and 4 weeks of detraining. Each group included two subgroups: males and females. After sacrificing, hearts were isolated and retrogradely perfused according to Langendorff technique. Levels of superoxide anion radical, hydrogen peroxide, nitrites and thiobarbituric acid reactive substances were measured in plasma and coronary venous effluent, while reduced glutathione, activities of superoxide dismutase and catalase were measured in erythrocytes. Our results indicate that swimming training doesn't promote oxidative damage, nor act protectively within the heart. However,