Evolutionary Origins of Enteric Hepatitis Viruses
Sander A. -., Corman V. M., Lukashev A. N., Doktor D. Ya. F.
Cold Spring Harbor Perspectives in Medicine
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.1101/cshperspect.a031690
Аннотация:
The enterically transmitted hepatitis A (HAV) and hepatitis E viruses (HEV) are the leading causes of acute viral hepatitis in humans. Despite the discovery of HAV and HEV 40-50 years ago, their evolutionary origins remain unclear. Recent discoveries of numerous nonprimate hepatoviruses and hepeviruses allow revisiting the evolutionary history of these viruses. In this review, we provide detailed phylogenomic analyses of primate and nonprimate hepatoviruses and hepeviruses. We identify conserved and divergent genomic properties and corroborate historical interspecies transmissions by phylogenetic comparisons and recombination analyses. We discuss the likely non-recent origins of human HAV and HEV precursors carried by mammals other than primates, and detail current zoonotic HEV infections. The novel nonprimate hepatoviruses and hepeviruses offer exciting new possibilities for future research focusing on host range and the unique biological properties of HAV and HEV. Copyright © 2018 Co
Ключевые слова:
animal; disease carrier; genetics; genotype; hepatitis A; Hepatitis A virus; hepatitis E; Hepatitis E virus; human; Human hepatitis A virus; mammal; molecular evolution; phylogeny; primate; virology; zoonosis; Animals; Disease Reservoirs; Evolution, Molecular; Genotype; Hepatitis A; Hepatitis A virus; Hepatitis A Virus, Human; Hepatitis E; Hepatitis E virus; Humans; Mammals; Phylogeny; Primates; Zoonoses
Язык текста: Английский
ISSN: 2157-1422
Sander A. -. A.-L.
Corman V. M.
Lukashev A. N. Aleksandr Nikolaevich 1977-
Doktor D. Ya. F. Dreksler Yan Feliks 1976-
Сандер А. -. А.-Л.
Cорман В. М.
Лукашев А. Н. Александр Николаевич 1977-
Доктор Д. Я. Ф. Дрекслер Ян Феликс 1976-
Evolutionary Origins of Enteric Hepatitis Viruses
Текст визуальный непосредственный
Cold Spring Harbor Perspectives in Medicine
Vol.8, Issue12
2018
Обзор
animal disease carrier genetics genotype hepatitis A Hepatitis A virus hepatitis E Hepatitis E virus human Human hepatitis A virus mammal molecular evolution phylogeny primate virology zoonosis Animals Disease Reservoirs Evolution, Molecular Genotype Hepatitis A Hepatitis A virus Hepatitis A Virus, Human Hepatitis E Hepatitis E virus Humans Mammals Phylogeny Primates Zoonoses
The enterically transmitted hepatitis A (HAV) and hepatitis E viruses (HEV) are the leading causes of acute viral hepatitis in humans. Despite the discovery of HAV and HEV 40-50 years ago, their evolutionary origins remain unclear. Recent discoveries of numerous nonprimate hepatoviruses and hepeviruses allow revisiting the evolutionary history of these viruses. In this review, we provide detailed phylogenomic analyses of primate and nonprimate hepatoviruses and hepeviruses. We identify conserved and divergent genomic properties and corroborate historical interspecies transmissions by phylogenetic comparisons and recombination analyses. We discuss the likely non-recent origins of human HAV and HEV precursors carried by mammals other than primates, and detail current zoonotic HEV infections. The novel nonprimate hepatoviruses and hepeviruses offer exciting new possibilities for future research focusing on host range and the unique biological properties of HAV and HEV. Copyright © 2018 Co