Analgesic activity of a natural peptide capable of specific binding to purinergic (P2x3) receptors
Паликова Y. А., Жармухамедова Т. Y., Паликов В. А., Хохлова О. Н., Осипова Г. А., Андреев Я. А., Логашина Ю. А., Козлов С. А., Яворскии А. Н., Мурашев А. Н., Д'Яченко И. А.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 3, С. 12-14
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.30906/0869-2092-2018-81-3-12-14
Аннотация:
Results of investigation of the analgesic activity of the natural recombinant peptide PT1, which specifically binds to P2X3 receptors, are presented. The test for hypersensitivity provoked by complete Freund's adjuvant (CFA) showed evidence of the analgesic activity of PT1 peptide in CD-I mice after single intravenous administration in a dose range of 0.01-1 mg/kg. © 2018 Izdatel'stvo Meditsina. All rights reserved.
Ключевые слова:
Analgesic activity; In vivo hypersensitivity model; Mice.; Natural peptides; P2X3 receptors
analgesic agent; Freund adjuvant; natural product; peptide derivative; peptide PTI; purinergic P2X3 receptor; unclassified drug; analgesic activity; animal experiment; Article; drug receptor binding; hypersensitivity; in vivo study; mouse; nonhuman; single drug dose
Язык текста: Русский
ISSN: 0869-2092
Паликова Y. А. Ю.А.
Жармухамедова Т. Y. Т.Ю.
Паликов В. А.
Хохлова О. Н.
Осипова Г. А.
Андреев Я. А. Ярослав Алексеевич 1979-
Логашина Ю. А. Юлия Александровна 1988-
Козлов С. А.
Яворскии А. Н.
Мурашев А. Н.
Д'Яченко И. А.
Palikova Y. A. Yu.A.
Zharmukhamedova T. Y. T.Yu.
Palikov V. A.
Khokhlova O. N.
Osipova G. A.
Andreev Ya. A. Yaroslav Alekseevich 1979-
Logashina Yu. A. Yuliya Aleksandrovna 1988-
Kozlov S. A.
Yavorskii A. N.
Murashev A. N.
D'Yachenko I. A.
Analgesic activity of a natural peptide capable of specific binding to purinergic (P2x3) receptors
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 3 С. 12-14
2018
Статья
Analgesic activity In vivo hypersensitivity model Mice. Natural peptides P2X3 receptors
analgesic agent Freund adjuvant natural product peptide derivative peptide PTI purinergic P2X3 receptor unclassified drug analgesic activity animal experiment Article drug receptor binding hypersensitivity in vivo study mouse nonhuman single drug dose
Results of investigation of the analgesic activity of the natural recombinant peptide PT1, which specifically binds to P2X3 receptors, are presented. The test for hypersensitivity provoked by complete Freund's adjuvant (CFA) showed evidence of the analgesic activity of PT1 peptide in CD-I mice after single intravenous administration in a dose range of 0.01-1 mg/kg. © 2018 Izdatel'stvo Meditsina. All rights reserved.