Dermotropic activity of the aqueous extract from caragana jubata shoots on the model of atopic contact dermatitis
Какорин П. А., Козин С. В., Раменская Г. В., Павлова Л. А.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 3, С. 28-33
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.30906/0869-2092-2018-81-3-28-33
Аннотация:
This research was aimed at the pharmacological analysis of dermotropic activity ofCaragana jubata (Pall.) poiraqueous extract on the model of atopic contact dermatitis induced by 2,4-dinitrochlorobenzene in male rats. It was found that the aqueous C. jubata extract exhibited expressed dermotropic activity as manifested by reducing thickness of the skin fold by 47[%] (p = 0.05) and decreasing severity of the onset of contact dermatitis on the average by 38[%] (p = 0.05). Histological examination showed positive trends in the regeneration of skin lesion. Hematologic examination showed normalization of peripheral blood parameters in animals affected by contact dermatitis. Calculations of the index of inhibition of the inflammatory response confirmed anti-inflammatory effect of the aqueous C. jubata extract. © 2018 Izdatel'stvo Meditsina. All rights reserved.
Ключевые слова:
2,4-dinitrochlorobenzene.; Caragana jubata (Pall.) Poir.; Contact dermatitis; Dermotropic activity
1 chloro 2,4 dinitrobenzene; antiinflammatory agent; Caragana jubata extract; dermatological agent; plant extract; unclassified drug; animal experiment; animal model; antiinflammatory activity; Article; atopic dermatitis; calculation; Caragana; Caragana jubata; contact dermatitis; disease severity; histopathology; male; nonhuman; rat; shoot; skinfold thickness
Язык текста: Русский
ISSN: 0869-2092
Какорин П. А. Павел Алексеевич 1991-
Козин С. В.
Раменская Г. В. Галина Владиславовна 1972-
Павлова Л. А.
Kakorin P. A. Pavel Alekseevich 1991-
Kozin S. V.
Ramenskaya G. V. Galina Vladislavovna 1972-
Pavlova L. A.
Dermotropic activity of the aqueous extract from caragana jubata shoots on the model of atopic contact dermatitis
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 3 С. 28-33
2018
Статья
2,4-dinitrochlorobenzene. Caragana jubata (Pall.) Poir. Contact dermatitis Dermotropic activity
1 chloro 2,4 dinitrobenzene antiinflammatory agent Caragana jubata extract dermatological agent plant extract unclassified drug animal experiment animal model antiinflammatory activity Article atopic dermatitis calculation Caragana Caragana jubata contact dermatitis disease severity histopathology male nonhuman rat shoot skinfold thickness
This research was aimed at the pharmacological analysis of dermotropic activity ofCaragana jubata (Pall.) poiraqueous extract on the model of atopic contact dermatitis induced by 2,4-dinitrochlorobenzene in male rats. It was found that the aqueous C. jubata extract exhibited expressed dermotropic activity as manifested by reducing thickness of the skin fold by 47[%] (p = 0.05) and decreasing severity of the onset of contact dermatitis on the average by 38[%] (p = 0.05). Histological examination showed positive trends in the regeneration of skin lesion. Hematologic examination showed normalization of peripheral blood parameters in animals affected by contact dermatitis. Calculations of the index of inhibition of the inflammatory response confirmed anti-inflammatory effect of the aqueous C. jubata extract. © 2018 Izdatel'stvo Meditsina. All rights reserved.