Scleroderma “en coup de sabre” With Epilepsy and Uveitis Successfully Treated With Tocilizumab [La esclerodermia «en coup de sabre» con epilepsia y...
Осминина М. К., Геппе Н. А., Афонина Е.
Reumatologia Clinica
Т. 16, Вып. 5, С. 356-358
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1016/j.reuma.2018.05.001
Аннотация:
Case history of a small girl outlet with epilepsy, followed by scleroderma skin damage and uveitis, neurovasculitis with white matter foci in brain on the side of skin lesion in two months, immunologic disease activity. Resistance to conventional immunosuppressive therapy forced us to initiate the treatment with tocilizumab. It was well tolerated and led to significant improvement of brain, ocular and skin manifestations. © 2018 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
Ключевые слова:
Epilepsy and uveitis; Scleroderma “en coup de sabre” with neurovasculitis; Tocilizumab treatment
carbamazepine; immunoglobulin G antibody; methotrexate; prednisone; tocilizumab; alopecia; Article; brain damage; Caucasian; child; clinical article; clonic seizure; continuous infusion; disease course; drug dose increase; drug dose reduction; electroencephalogram; epilepsy; female; focal epilepsy; human; hyperpigmentation; iridocyclitis; muscle weakness; nuclear magnetic resonance imaging; scleroderma; skin color; tendon reflex; treatment outcome; unconsciousness; uveitis; vomiting; white matter injury; case report
Язык текста: Русский
ISSN: 1699-258X
Осминина М. К. Мария Кирилловна 1963-
Геппе Н. А. Наталья Анатольевна 1946-
Афонина Е.
Osminina M. K. Mariya Kirillovna 1963-
Geppe N. A. Natal`ya Anatolyevna 1946-
Afonina E.
Scleroderma “en coup de sabre” With Epilepsy and Uveitis Successfully Treated With Tocilizumab [La esclerodermia «en coup de sabre» con epilepsia y uveítis se trata con éxito con tocilizumab]
Scleroderma “en coup de sabre” With Epilepsy and Uveitis Successfully Treated With Tocilizumab [La esclerodermia «en coup de sabre» con epilepsia y...
Текст визуальный непосредственный
Reumatologia Clinica
Doyma
Т. 16, Вып. 5 С. 356-358
2020
Статья
Epilepsy and uveitis Scleroderma “en coup de sabre” with neurovasculitis Tocilizumab treatment
carbamazepine immunoglobulin G antibody methotrexate prednisone tocilizumab alopecia Article brain damage Caucasian child clinical article clonic seizure continuous infusion disease course drug dose increase drug dose reduction electroencephalogram epilepsy female focal epilepsy human hyperpigmentation iridocyclitis muscle weakness nuclear magnetic resonance imaging scleroderma skin color tendon reflex treatment outcome unconsciousness uveitis vomiting white matter injury case report
Case history of a small girl outlet with epilepsy, followed by scleroderma skin damage and uveitis, neurovasculitis with white matter foci in brain on the side of skin lesion in two months, immunologic disease activity. Resistance to conventional immunosuppressive therapy forced us to initiate the treatment with tocilizumab. It was well tolerated and led to significant improvement of brain, ocular and skin manifestations. © 2018 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología