Comparative Study of the Severity of Renal Damage in Newborn and Adult Rats under Conditions of Ischemia/Reperfusion and Endotoxin Administration
Pevzner I. B., Pavlenko T. A., Popkov V. A., Andrianova N. V., Zorova L. D., Brezgunova A. A., Zorov S. D., Yankauskas S. S., Silachev D. N., Zorov D. B., Plotnikov E. Yu.
Bulletin of Experimental Biology and Medicine
Vol.165, Issue2, P. 189-194
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1007/s10517-018-4127-5
Аннотация:
Oxidative kidney injury was compared in newborn and adult rats under conditions of ischemia/reperfusion and in experimental model of systemic inflammation induced by endotoxin (LPS of bacterial cell wall) administration. Oxidative stress in the kidney accompanied both experimental models, but despite similar oxidative tissue damage, kidney dysfunction in neonates was less pronounced than in adult animals. It was found that neonatal kidney has a more potent regenerative potential with higher level of cell proliferation than adult kidney, where the level proliferating cell antigen (PCNA) increased only on day 2 after ischemia/reperfusion. The pathological process in the neonatal kidney developed against the background of active cell proliferation, and, as a result, proliferating cells could almost immediately replace the damaged structures. In the adult kidney, regeneration of the renal tissue was activated only after significant loss of functional nephrons and impairment of renal functi
Ключевые слова:
age; ischemia; oxidative stress; regeneration; sepsis
endotoxin; endotoxin; adult; animal cell; animal experiment; animal tissue; Article; cell proliferation; comparative study; kidney cell; kidney dysfunction; kidney injury; kidney tissue; nephron; newborn; nonhuman; oxidative stress; rat; reperfusion injury; tissue regeneration; acute kidney failure; age; aging; animal; chemically induced; complication; cytology; female; ischemia; kidney; male; pathology; pathophysiology; physiology; regeneration; reperfusion injury; severity of illness index; Acute Kidney Injury; Age Factors; Aging; Animals; Animals, Newborn; Endotoxins; Female; Ischemia; Kidney; Male; Rats; Regeneration; Reperfusion Injury; Severity of Illness Index
Язык текста: Английский
ISSN: 1573-8221
Pevzner I. B.
Pavlenko T. A.
Popkov V. A.
Andrianova N. V.
Zorova L. D.
Brezgunova A. A.
Zorov S. D.
Yankauskas S. S.
Silachev D. N.
Zorov D. B.
Plotnikov E. Yu. Egor Yuryevich 1980-
Певзнер И. Б.
Павленко Т. А.
Попков В. А.
Андрианова Н. В.
Зорова Л. Д.
Брезгунова А. А.
Зоров С. Д.
Янкаускас С. С.
Силачев Д. Н.
Зоров Д. Б.
Плотников Е. Ю. Егор Юрьевич 1980-
Comparative Study of the Severity of Renal Damage in Newborn and Adult Rats under Conditions of Ischemia/Reperfusion and Endotoxin Administration
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.165, Issue2 P. 189-194
2018
Статья
age ischemia oxidative stress regeneration sepsis
endotoxin endotoxin adult animal cell animal experiment animal tissue Article cell proliferation comparative study kidney cell kidney dysfunction kidney injury kidney tissue nephron newborn nonhuman oxidative stress rat reperfusion injury tissue regeneration acute kidney failure age aging animal chemically induced complication cytology female ischemia kidney male pathology pathophysiology physiology regeneration reperfusion injury severity of illness index Acute Kidney Injury Age Factors Aging Animals Animals, Newborn Endotoxins Female Ischemia Kidney Male Rats Regeneration Reperfusion Injury Severity of Illness Index
Oxidative kidney injury was compared in newborn and adult rats under conditions of ischemia/reperfusion and in experimental model of systemic inflammation induced by endotoxin (LPS of bacterial cell wall) administration. Oxidative stress in the kidney accompanied both experimental models, but despite similar oxidative tissue damage, kidney dysfunction in neonates was less pronounced than in adult animals. It was found that neonatal kidney has a more potent regenerative potential with higher level of cell proliferation than adult kidney, where the level proliferating cell antigen (PCNA) increased only on day 2 after ischemia/reperfusion. The pathological process in the neonatal kidney developed against the background of active cell proliferation, and, as a result, proliferating cells could almost immediately replace the damaged structures. In the adult kidney, regeneration of the renal tissue was activated only after significant loss of functional nephrons and impairment of renal functi