Аннотация:
Hereditary thrombophilias (HT) and undifferentiated connective tissue dysplasia (uCTD) are important causes of female infertility. Moreover, there are signs of their common pathogenesis: a number of proteins, such as PAI-1, play an important role in the pathogenesis of both conditions, as well as in the development of infertility in patients with HT and uCTD Objective — to determine the morphological substrate and molecular mechanisms of impaired pregnancy outcomes in women with uCTD and HT. Subject and methods. A study group included 130 reproductive-aged female patients with primary infertility and a control group consisted of 11 patients (surrogate mothers). An endometrial pipelle biopsy sample was taken from each patient on days 6—8 after ovulation according to the ultrasound findings. The study group patients were divided into subgroups: 1A) infertility and HT (n=91); 1B) infertility, NT, and uCTD (n=19); 1C) infertility and uCTD (n=20). The investigators examined obstetric/gyneco
Ключевые слова:
Hereditary thrombophilias; Osteopontin; PAI-1; Undifferentiated connective tissue dysplasia
complication; connective tissue; connective tissue disease; female; female infertility; human; pregnancy; pregnancy outcome; thrombophilia; Connective Tissue; Connective Tissue Diseases; Female; Humans; Infertility, Female; Pregnancy; Pregnancy Outcome; Thrombophilia
Демура Т. А. Татьяна Александровна 1983-
Коган Е. А. Евгения Алтаровна 1951-
Занозин А. С. Александр Сергеевич 1989-
Колосовскy Д. Y.
Demura T. A. Tat`yana Aleksandrovna 1983-
Kogan E. A. Evgeniya Altarovna 1951-
Zanozin A. S. Aleksandr Sergeevich 1989-
Kolosovsky D. Y.
The morphological substrate and molecular mechanisms of impaired pregnancy outcomes in women with hereditary thrombophilias and undifferentiated connective tissue dysplasia
The morphological substrate and molecular mechanisms of impaired pregnancy outcomes in women with hereditary thrombophilias and undifferentiated...
Текст визуальный непосредственный
Архив патологии
Издательство Медиа Сфера
Т. 80, Вып. 5 С. 33-39
2018
Статья
Hereditary thrombophilias Osteopontin PAI-1 Undifferentiated connective tissue dysplasia
complication connective tissue connective tissue disease female female infertility human pregnancy pregnancy outcome thrombophilia Connective Tissue Connective Tissue Diseases Female Humans Infertility, Female Pregnancy Pregnancy Outcome Thrombophilia
Hereditary thrombophilias (HT) and undifferentiated connective tissue dysplasia (uCTD) are important causes of female infertility. Moreover, there are signs of their common pathogenesis: a number of proteins, such as PAI-1, play an important role in the pathogenesis of both conditions, as well as in the development of infertility in patients with HT and uCTD Objective — to determine the morphological substrate and molecular mechanisms of impaired pregnancy outcomes in women with uCTD and HT. Subject and methods. A study group included 130 reproductive-aged female patients with primary infertility and a control group consisted of 11 patients (surrogate mothers). An endometrial pipelle biopsy sample was taken from each patient on days 6—8 after ovulation according to the ultrasound findings. The study group patients were divided into subgroups: 1A) infertility and HT (n=91); 1B) infertility, NT, and uCTD (n=19); 1C) infertility and uCTD (n=20). The investigators examined obstetric/gyneco