Аннотация:
Today it is noted that the most cases of the hypospadias, cryptorchidism, testicular microlithiasis, as well as problems of semen quality and testicular germ cell tumours can be a clinical manifestation of testicular dysgenesis syndrome caused by abnormal development of reproductive organs. In the last decade, technological progress in the molecular genetics has made possible to carry out a directed search for genetic factors associated with reproductive disorders in men. In the review we attempted to analyze available literature data on the testicular dysgenesis syndrome and its constituent condition and also to consider the risk factors associated with its development. We give particular attention to the consideration of genetic factors that determine the manifestation of testicular microlithiasis, cryptorchidism and testicular germ cell tumors, both individual clinical conditions and in the syndrome of testicular dysgenesis. Knowledge of the genetic aspects of reproductive damage wi
Немцова М. В. Марина Вячеславовна 1962-
Данцев И. С.
Михайленко Д. С. Дмитрий Сергеевич 1981-
Лоран О. Б.
Nemtsova M. V. Marina Vyacheslavovna 1962-
Dantsev I. S.
Mikhaylenko D. S. Dmitrij Sergeevich 1981-
Loran O. B.
Genetic aspects of testicular dysgenesis syndrome and associated conditions
Текст визуальный непосредственный
Онкоурология
Издательский дом "АБВ-пресс"
Т. 14, Вып. 3 С. 92-106
2018
Статья
High-risk genotype Risk factor Single nucleotide polymorphism (SNP) Testicular dysgenesis syndrome Testicular germ cell tumor Testicular microlithiasis
Today it is noted that the most cases of the hypospadias, cryptorchidism, testicular microlithiasis, as well as problems of semen quality and testicular germ cell tumours can be a clinical manifestation of testicular dysgenesis syndrome caused by abnormal development of reproductive organs. In the last decade, technological progress in the molecular genetics has made possible to carry out a directed search for genetic factors associated with reproductive disorders in men. In the review we attempted to analyze available literature data on the testicular dysgenesis syndrome and its constituent condition and also to consider the risk factors associated with its development. We give particular attention to the consideration of genetic factors that determine the manifestation of testicular microlithiasis, cryptorchidism and testicular germ cell tumors, both individual clinical conditions and in the syndrome of testicular dysgenesis. Knowledge of the genetic aspects of reproductive damage wi