Размер шрифта
Цветовая схема
Изображения
Форма
Межсимвольный интервал
Межстрочный интервал
стандартные настройки
обычная версия сайта
закрыть
  • Вход
  • Регистрация
  • Помощь
Выбрать БД
Простой поискРасширенный поискИстория поисков
Главная / Результаты поиска

Genetic characterization of Plasmodium vivax in the Kyrgyz Republic

Goryacheva I. I., Baranova A. M., Lukashev A. N., Gordeev M. I., Usenbaev N. T., Shaikevich E. V.
Infection, Genetics and Evolution
Vol.66, P. 262-268
Опубликовано: 2018
Тип ресурса: Статья

DOI:10.1016/j.meegid.2018.10.009

Аннотация:
At the end of 2016, Kyrgyz Republic was certified by the World Health Organization as a malaria-free country, while only a decade ago this disease posed a serious health threat. The progress achieved by Kyrgyz Republic provides a unique example of tertian (Plasmodium vivax) malaria elimination. This success was based on an integrated approach, including measures for the treatment of infected people and disease prevention, vector control and the development of an effective national epidemiological surveillance system. Lower P. vivax msp-1, msp-3α csp and dbpII genes polymorphism was revealed in Kyrgyz Republic in compare with that in Tajikistan. Molecular characterization of the causative agent found that P. vivax populations in Kyrgyz Republic was comprised by several lineages, highly divergent in the south-western and genetically homogeneous in the northern regions of Kyrgyz Republic, d. Such profile in the northern regions was compatible with several recent introductions rather than
Ключевые слова:
Antimalarial measures; Genetic variability; Malaria; Plasmodium vivax
protozoal DNA; RNA 18S; Article; csp gene; dbpII gene; DNA extraction; gene; genetic analysis; genetic polymorphism; genetic variability; genetic variation; Kyrgyzstan; malaria control; msp 1 genne; msp 3alpha gene; nonhuman; parasite clearance; phylogeny; Plasmodium vivax; polymerase chain reaction; priority journal; sequence analysis; species difference; allele; DNA sequence; genetics; haplotype; human; Kyrgyzstan; nucleotide sequence; parasitology; Plasmodium vivax; Plasmodium vivax malaria; Alleles; Base Sequence; Genes, Protozoan; Genetic Variation; Haplotypes; Humans; Kyrgyzstan; Malaria, Vivax; Phylogeny; Plasmodium vivax; Polymorphism, Genetic; RNA, Ribosomal, 18S; Sequence Analysis, DNA
Язык текста: Английский
ISSN: 1567-7257
Goryacheva I. I.
Baranova A. M. Alla Mikhaylovna 1944-
Lukashev A. N. Aleksandr Nikolaevich 1977-
Gordeev M. I.
Usenbaev N. T.
Shaikevich E. V.
Горячева И. И.
Баранова А. М. Алла Михайловна 1944-
Лукашев А. Н. Александр Николаевич 1977-
Гордеев М. И.
Усенбаев Н. Т.
Шаикевич Е. В.
Genetic characterization of Plasmodium vivax in the Kyrgyz Republic
Текст визуальный непосредственный
Infection, Genetics and Evolution
Elsevier Science Publisher B.V.
Vol.66 P. 262-268
2018
Статья
Antimalarial measures Genetic variability Malaria Plasmodium vivax
protozoal DNA RNA 18S Article csp gene dbpII gene DNA extraction gene genetic analysis genetic polymorphism genetic variability genetic variation Kyrgyzstan malaria control msp 1 genne msp 3alpha gene nonhuman parasite clearance phylogeny Plasmodium vivax polymerase chain reaction priority journal sequence analysis species difference allele DNA sequence genetics haplotype human Kyrgyzstan nucleotide sequence parasitology Plasmodium vivax Plasmodium vivax malaria Alleles Base Sequence Genes, Protozoan Genetic Variation Haplotypes Humans Kyrgyzstan Malaria, Vivax Phylogeny Plasmodium vivax Polymorphism, Genetic RNA, Ribosomal, 18S Sequence Analysis, DNA
At the end of 2016, Kyrgyz Republic was certified by the World Health Organization as a malaria-free country, while only a decade ago this disease posed a serious health threat. The progress achieved by Kyrgyz Republic provides a unique example of tertian (Plasmodium vivax) malaria elimination. This success was based on an integrated approach, including measures for the treatment of infected people and disease prevention, vector control and the development of an effective national epidemiological surveillance system. Lower P. vivax msp-1, msp-3α csp and dbpII genes polymorphism was revealed in Kyrgyz Republic in compare with that in Tajikistan. Molecular characterization of the causative agent found that P. vivax populations in Kyrgyz Republic was comprised by several lineages, highly divergent in the south-western and genetically homogeneous in the northern regions of Kyrgyz Republic, d. Such profile in the northern regions was compatible with several recent introductions rather than