Regenerative Potential of Spinal Ganglion Neurons During Topical Administration of Platelet-Enriched Blood Plasma Into the Skin Wound
Fetisov S. O., Nikituk D. B., Klochkova S. V., Alekseeva N. T., Kvaratskheliya A. G.
Bulletin of Experimental Biology and Medicine
Vol.165, Issue6, P. 808-812
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1007/s10517-018-4270-z
Аннотация:
We studied the reactions of spinal ganglion neurons accompanying regeneration of the skin wound complicated by S. aureus sp. infection. The appearance of neuron groups with different morphofunctional changes was noted: reversible dystrophic and compensatory reactions and irreversible degenerative changes. The proportion of small B neurons was higher than the proportion of large type A neurons at all terms of the experiment. Application of plateletrich plasma to the wound after preliminary hydroimpulsive treatment considerably reduced cell destruction and stimulated regenerative effects in neurons starting from day 7 of the experiment. Application of platelet-rich plasma without hydroimpulsive treatment decelerated wound regeneration and increased the number of destructively changed neurons even in comparison with spontaneous wound healing. Close correlations between protein synthesis markers and stages of the wound process and its characteristics were revealed. © 2018, Springer Science
Ключевые слова:
platelet-reach blood plasma; skin wound; spinal ganglion
animal experiment; animal model; animal tissue; Article; cell destruction; cell regeneration; cell size; cell structure; comparative study; controlled study; male; nerve cell degeneration; nerve cell differentiation; nerve regeneration; nonhuman; protein synthesis; rat; regenerative ability; regenerative medicine; sensory nerve cell; skin injury; Staphylococcus infection; thrombocyte rich plasma; wound healing; animal; cytology; injuries; microbiology; nerve cell; procedures; skin; spinal ganglion; Staphylococcus aureus; time factor; wound healing; Animals; Ganglia, Spinal; Male; Nerve Regeneration; Neurons; Platelet-Rich Plasma; Rats; Regenerative Medicine; Skin; Staphylococcal Infections; Staphylococcus aureus; Time Factors; Wound Healing
Язык текста: Английский
ISSN: 1573-8221
Fetisov S. O.
Nikituk D. B. Dmitrij Borisovich 1962-
Klochkova S. V. Svetlana Valeryevna 1968-
Alekseeva N. T.
Kvaratskheliya A. G.
Фетисов С. О.
Никитюк Д. Б. Дмитрий Борисович 1962-
Клочкова С. В. Светлана Валерьевна 1968-
Алексеева Н. Т.
Кварацхелия А. Г.
Regenerative Potential of Spinal Ganglion Neurons During Topical Administration of Platelet-Enriched Blood Plasma Into the Skin Wound
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.165, Issue6 P. 808-812
2018
Статья
platelet-reach blood plasma skin wound spinal ganglion
animal experiment animal model animal tissue Article cell destruction cell regeneration cell size cell structure comparative study controlled study male nerve cell degeneration nerve cell differentiation nerve regeneration nonhuman protein synthesis rat regenerative ability regenerative medicine sensory nerve cell skin injury Staphylococcus infection thrombocyte rich plasma wound healing animal cytology injuries microbiology nerve cell procedures skin spinal ganglion Staphylococcus aureus time factor wound healing Animals Ganglia, Spinal Male Nerve Regeneration Neurons Platelet-Rich Plasma Rats Regenerative Medicine Skin Staphylococcal Infections Staphylococcus aureus Time Factors Wound Healing
We studied the reactions of spinal ganglion neurons accompanying regeneration of the skin wound complicated by S. aureus sp. infection. The appearance of neuron groups with different morphofunctional changes was noted: reversible dystrophic and compensatory reactions and irreversible degenerative changes. The proportion of small B neurons was higher than the proportion of large type A neurons at all terms of the experiment. Application of plateletrich plasma to the wound after preliminary hydroimpulsive treatment considerably reduced cell destruction and stimulated regenerative effects in neurons starting from day 7 of the experiment. Application of platelet-rich plasma without hydroimpulsive treatment decelerated wound regeneration and increased the number of destructively changed neurons even in comparison with spontaneous wound healing. Close correlations between protein synthesis markers and stages of the wound process and its characteristics were revealed. © 2018, Springer Science