Аннотация:
In addition to accumulation and metabolism of triglycerides, white adipose tissue is recognized as the active endocrine organ, whose dysfunction is associated with the development of a wide range of diseases. The secretome of adipocytes is represented by a wide range of adipokines, which vary in depot and sex-specific manner. In addition, adipokines have diverse biological effects, correlations with different metabolic features and functions. In this review, the data on biological effects, origin and the clinical significance of adipokines are discussed. The influence of adipokines on metabolism, sensitivity to insulin, vascular homeostasis, angiogenesis, repair, inflammation and immune cells are shown. Visceral adipose tissue accumulation is accompanied with adipocytes hypertrophy and overproduction of such proinflammatory and proaterogenic molecules like resistin, visfatin, vaspin, tumor necrosis factor, interleukin 6, lipocalin, glypican 4, RBP4 etc. There is a tight correlation bet
Ключевые слова:
adipocytokine; biological marker; triacylglycerol; angiogenesis; cardiovascular disease; cytology; gene expression regulation; genetics; human; immunology; insulin resistance; metabolism; metabolome; neoplasm; non insulin dependent diabetes mellitus; pathology; sex factor; signal transduction; white adipocyte; white adipose tissue; Adipocytes, White; Adipokines; Adipose Tissue, White; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Gene Expression Regulation; Humans; Insulin Resistance; Metabolome; Neoplasms; Neovascularization, Physiologic; Sex Factors; Signal Transduction; Triglycerides
Сулаиева О.
Черешнева Е. В. Елизавета Васильевна 1977-
Карташкина Н. Л. Наталия Левоновна 1983-
Иванова М.
Цомартова Д. А. Дибахан Асланбековна 1966-
Sulaieva O.
Chereshneva E. V. Elizaveta Vasilyevna 1977-
Kartashkina N. L. Nataliya Levonovna 1983-
Ivanova M.
Tsomartova D. A. Dibakhan Aslanbekovna 1966-
SECRETORY FUNCTION OF WHITE ADIPOSE TISSUE AND ADIPOKINES: BIOLOGICAL EFFECTS AND CLINICAL SIGNIFICANCE (REVIEW)
Текст визуальный непосредственный
Georgian Medical News
Ассоциация деловой прессы Грузии
Вып. 274 С. 116-124
2018
Обзор
adipocytokine biological marker triacylglycerol angiogenesis cardiovascular disease cytology gene expression regulation genetics human immunology insulin resistance metabolism metabolome neoplasm non insulin dependent diabetes mellitus pathology sex factor signal transduction white adipocyte white adipose tissue Adipocytes, White Adipokines Adipose Tissue, White Biomarkers Cardiovascular Diseases Diabetes Mellitus, Type 2 Gene Expression Regulation Humans Insulin Resistance Metabolome Neoplasms Neovascularization, Physiologic Sex Factors Signal Transduction Triglycerides
In addition to accumulation and metabolism of triglycerides, white adipose tissue is recognized as the active endocrine organ, whose dysfunction is associated with the development of a wide range of diseases. The secretome of adipocytes is represented by a wide range of adipokines, which vary in depot and sex-specific manner. In addition, adipokines have diverse biological effects, correlations with different metabolic features and functions. In this review, the data on biological effects, origin and the clinical significance of adipokines are discussed. The influence of adipokines on metabolism, sensitivity to insulin, vascular homeostasis, angiogenesis, repair, inflammation and immune cells are shown. Visceral adipose tissue accumulation is accompanied with adipocytes hypertrophy and overproduction of such proinflammatory and proaterogenic molecules like resistin, visfatin, vaspin, tumor necrosis factor, interleukin 6, lipocalin, glypican 4, RBP4 etc. There is a tight correlation bet