A novel lipopeptaibol emericellipsin a with antimicrobial and antitumor activity produced by the extremophilic fungus emericellopsis alkalina
Rogozhin E. A., Sadykova V. S., Baranova A. A., Vasilchenko A. S., Lushpa V. A., Mineev K. S., Georgieva M. L., Kul'ko A. B., Krasheninnikov M. E., Lyundup A. V., Vasilchenko A. V., Andreev Ya. A.
Molecules
Vol.23, Issue11, Num.23112785
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.3390/molecules23112785
Аннотация:
Soil fungi are known to contain a rich variety of defense metabolites that allow them to compete with other organisms (fungi, bacteria, nematodes, and insects) and help them occupy more preferential areas at the expense of effective antagonism. These compounds possess antibiotic activity towards a wide range of other microbes, particularly fungi that belong to different taxonomical units. These compounds include peptaibols, which are non-ribosomal synthesized polypeptides containing non-standard amino acid residues (alpha-aminoisobutyric acid mandatory) and some posttranslational modifications. We isolated a novel antibiotic peptide from the culture medium of Emericellopsis alkalina, an alkalophilic strain. This peptide, called emericellipsin A, exhibited a strong antifungal effect against the yeast Candida albicans, the mold fungus Aspergillus Niger, and human pathogen clinical isolates. It also exhibited antimicrobial activity against some Gram-positive and Gram-negative bacteria. Ad
Ключевые слова:
Peptaibol; emericellipsin A; Emericellopsis alkalina; 2D structure; antifungal activity; antibacterial activity; cytotoxic properties
antiinfective agent; antineoplastic agent; Ascomycetes; bacterium; cell survival; chemical structure; chemistry; drug effect; fungus; high performance liquid chromatography; human; isolation and purification; mass spectrometry; metabolism; microbial sensitivity test; nuclear magnetic resonance spectroscopy; tumor cell line; Anti-Infective Agents; Antineoplastic Agents; Ascomycota; Bacteria; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Fungi; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Structure
Язык текста: Английский
ISSN: 1420-3049
Rogozhin E. A.
Sadykova V. S.
Baranova A. A.
Vasilchenko A. S.
Lushpa V. A.
Mineev K. S.
Georgieva M. L.
Kul'ko A. B.
Krasheninnikov M. E. Mikhail Evgenyevich 1959-
Lyundup A. V. Aleksej Valeryevich 1983-
Vasilchenko A. V.
Andreev Ya. A. Yaroslav Alekseevich 1979-
Рогожин Е. А.
Садyкова В. С.
Баранова А. А.
Василченко А. С.
Лушпа В. А.
Минеев К. С.
Георгиева М. Л.
Кул'ко А. Б.
Крашенинников М. Е. Михаил Евгеньевич 1959-
Люндуп А. В. Алексей Валерьевич 1983-
Василченко А. В.
Андреев Я. А. Ярослав Алексеевич 1979-
A novel lipopeptaibol emericellipsin a with antimicrobial and antitumor activity produced by the extremophilic fungus emericellopsis alkalina
Текст визуальный непосредственный
Molecules
Springer-Verlag GmbH
Vol.23, Issue11 Num.23112785
2018
Статья
Peptaibol emericellipsin A Emericellopsis alkalina 2D structure antifungal activity antibacterial activity cytotoxic properties
antiinfective agent antineoplastic agent Ascomycetes bacterium cell survival chemical structure chemistry drug effect fungus high performance liquid chromatography human isolation and purification mass spectrometry metabolism microbial sensitivity test nuclear magnetic resonance spectroscopy tumor cell line Anti-Infective Agents Antineoplastic Agents Ascomycota Bacteria Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Fungi Humans Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Molecular Structure
Soil fungi are known to contain a rich variety of defense metabolites that allow them to compete with other organisms (fungi, bacteria, nematodes, and insects) and help them occupy more preferential areas at the expense of effective antagonism. These compounds possess antibiotic activity towards a wide range of other microbes, particularly fungi that belong to different taxonomical units. These compounds include peptaibols, which are non-ribosomal synthesized polypeptides containing non-standard amino acid residues (alpha-aminoisobutyric acid mandatory) and some posttranslational modifications. We isolated a novel antibiotic peptide from the culture medium of Emericellopsis alkalina, an alkalophilic strain. This peptide, called emericellipsin A, exhibited a strong antifungal effect against the yeast Candida albicans, the mold fungus Aspergillus Niger, and human pathogen clinical isolates. It also exhibited antimicrobial activity against some Gram-positive and Gram-negative bacteria. Ad