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Recent advances in trypanosomatid research: Genome organization, expression, metabolism, taxonomy and evolution

Maslov D. A., Opperdoes F. R., Kostygov A. Y., Hashimi H., Lukeš J., Yurchenko V.
Parasitology
Vol.146, Issue1, P. 1-27
Опубликовано: 2019
Тип ресурса: Статья

DOI:10.1017/S0031182018000951

Аннотация:
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number of diseases in humans, domestic animals and plants. Their monoxenous relatives are restricted to insects. Because of the high biological diversity, adaptability to dramatically different environmental conditions, and omnipresence, these protists have major impact on all biotic communities that still needs to be fully elucidated. In addition, as these organisms represent a highly divergent evolutionary lineage, they are strikingly different from the common 'model system' eukaryotes, such as some mammals, plants or fungi. A number of excellent reviews, published over the past decade, were dedicated to specialized topics from the areas of trypanosomatid molecular and cell biology, biochemistry, host-parasite relationships or other aspects of these fascinating organisms. However, there is a need for a more comprehensi
Ключевые слова:
Gene exchange; kinetoplast; metabolism; molecular and cell biology; taxonomy; trypanosomatidae
kinetoplast DNA; messenger RNA; mitochondrial protein; mitochondrial RNA binding complex 1; proteome; protozoal RNA; RNA binding protein; RNA polymerase; unclassified drug; acidocalcisome; Article; cell function; cell organelle; codon; complex formation; cytosol; DNA replication; endosymbiont; enzyme activity; eukaryotic flagellum; evolutionary adaptation; gene expression; gene loss; genome analysis; glycosome; kinetoplast; kinetoplastid life cycle stage; mathematical model; metabolism; molecular evolution; molecular recognition; nonhuman; polyadenylation; population structure; priority journal; protein synthesis; proteomics; RNA cleavage; RNA editing; RNA processing; RNA transcription; solute; species differentiation; taxonomy; trans splicing; translation regulation; Trypanosomatidae; animal; classification; evolution; gene expression regulation; genetics; genome; human; metabolism; phylogeny; Animals; Biological Evolution; Gene Expression Regulation; Genome, Protozoan; Humans; Phylog
Язык текста: Английский
ISSN: 1469-8161
Maslov D. A.
Opperdoes F. R.
Kostygov A. Y.
Hashimi H.
Lukeš J.
Yurchenko V. Vyacheslav 1972-
Маслов Д. А.
Оппердоес Ф. Р.
Костyгов А. Y.
Хашими Х.
Лукеš Й.
Юрченко В. Вячеслав 1972-
Recent advances in trypanosomatid research: Genome organization, expression, metabolism, taxonomy and evolution
Текст визуальный непосредственный
Parasitology
Cambridge University Press
Vol.146, Issue1 P. 1-27
2019
Статья
Gene exchange kinetoplast metabolism molecular and cell biology taxonomy trypanosomatidae
kinetoplast DNA messenger RNA mitochondrial protein mitochondrial RNA binding complex 1 proteome protozoal RNA RNA binding protein RNA polymerase unclassified drug acidocalcisome Article cell function cell organelle codon complex formation cytosol DNA replication endosymbiont enzyme activity eukaryotic flagellum evolutionary adaptation gene expression gene loss genome analysis glycosome kinetoplast kinetoplastid life cycle stage mathematical model metabolism molecular evolution molecular recognition nonhuman polyadenylation population structure priority journal protein synthesis proteomics RNA cleavage RNA editing RNA processing RNA transcription solute species differentiation taxonomy trans splicing translation regulation Trypanosomatidae animal classification evolution gene expression regulation genetics genome human metabolism phylogeny Animals Biological Evolution Gene Expression Regulation Genome, Protozoan Humans Phylog
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number of diseases in humans, domestic animals and plants. Their monoxenous relatives are restricted to insects. Because of the high biological diversity, adaptability to dramatically different environmental conditions, and omnipresence, these protists have major impact on all biotic communities that still needs to be fully elucidated. In addition, as these organisms represent a highly divergent evolutionary lineage, they are strikingly different from the common 'model system' eukaryotes, such as some mammals, plants or fungi. A number of excellent reviews, published over the past decade, were dedicated to specialized topics from the areas of trypanosomatid molecular and cell biology, biochemistry, host-parasite relationships or other aspects of these fascinating organisms. However, there is a need for a more comprehensi