New approach to diagnosis, immunophenotypic verification and prognostic prediction for renal angiomyolipoma
Демяшкин Г. А., Заборскии И. Н.
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.18565/urology.2018.1.35-41
Аннотация:
Renal angiomyolipoma (AML) is a rare benign neoplasm of mesenchymal origin. AML incidence varies from 0.3 to 5[%], while women suffer four times more often than men. In most cases, renal AML measures less than 4 cm, is asymptomatic and detected accidentally with computed tomography or ultrasound. A histological variant of AML need to be verified to choose management strategy and reduce the risk of complications. Histological and immunohistochemical assessment of biopsy and surgical specimens has an essential diagnostic value in determining the type and subtypes of renal neoplasms and the risk of malignancy. The study aimed to investigate pathomorphological and prognostic features (immunohistochemical characteristics) of renal AML.MATERIALS AND METHODS: Patients (n=42) with CT-detected renal neoplasms underwent partial nephrectomy. The majority (n=34) of patients was admitted to the hospital urgently, often without symptoms (n=23). The surgical specimens studied were examined using light
Ключевые слова:
-SMA; diagnosis of renal angiomyolipoma; HMB-45; Melan-A; renal angiomyolipoma
adult; aged; angiomyolipoma; diagnostic imaging; female; human; immunohistochemistry; kidney; kidney tumor; male; middle aged; nephrectomy; pathology; predictive value; procedures; prognosis; retrospective study; x-ray computed tomography; Adult; Aged; Angiomyolipoma; Female; Humans; Immunohistochemistry; Kidney; Kidney Neoplasms; Male; Middle Aged; Nephrectomy; Predictive Value of Tests; Prognosis; Retrospective Studies; Tomography, X-Ray Computed
Язык текста: Русский
ISSN: 1728-2985
Демяшкин Г. А. Григорий Александрович 1976-
Заборскии И. Н.
Demyashkin G. A. Grigorij Aleksandrovich 1976-
Zaborskii I. N.
New approach to diagnosis, immunophenotypic verification and prognostic prediction for renal angiomyolipoma
Текст визуальный непосредственный
Урология
Бионика Медиа
Вып. 1 С. 35-41
2018
Статья
-SMA diagnosis of renal angiomyolipoma HMB-45 Melan-A renal angiomyolipoma
adult aged angiomyolipoma diagnostic imaging female human immunohistochemistry kidney kidney tumor male middle aged nephrectomy pathology predictive value procedures prognosis retrospective study x-ray computed tomography Adult Aged Angiomyolipoma Female Humans Immunohistochemistry Kidney Kidney Neoplasms Male Middle Aged Nephrectomy Predictive Value of Tests Prognosis Retrospective Studies Tomography, X-Ray Computed
Renal angiomyolipoma (AML) is a rare benign neoplasm of mesenchymal origin. AML incidence varies from 0.3 to 5[%], while women suffer four times more often than men. In most cases, renal AML measures less than 4 cm, is asymptomatic and detected accidentally with computed tomography or ultrasound. A histological variant of AML need to be verified to choose management strategy and reduce the risk of complications. Histological and immunohistochemical assessment of biopsy and surgical specimens has an essential diagnostic value in determining the type and subtypes of renal neoplasms and the risk of malignancy. The study aimed to investigate pathomorphological and prognostic features (immunohistochemical characteristics) of renal AML.MATERIALS AND METHODS: Patients (n=42) with CT-detected renal neoplasms underwent partial nephrectomy. The majority (n=34) of patients was admitted to the hospital urgently, often without symptoms (n=23). The surgical specimens studied were examined using light