The effects of l-cysteine and N-acetyl-l-cysteine on homocysteine metabolism and haemostatic markers, and on cardiac and aortic histology in...
Kostić S., Mićovic Ž., Andrejević L., Cvetković S., Stamenković A., Stanković S., Obrenović R., Labudović-Borović M., Hrnčić D., Yakovlevich V., Djurić D.
Molecular and Cellular Biochemistry
Vol.451, Issue1-2, P. 43-54
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s11010-018-3391-z
Аннотация:
Methionine is the precursor of homocysteine, a sulfur amino acid intermediate in the methylation and transsulfuration pathways; methionine-rich diets were used to induce hyperhomocysteinemia, and cardiovascular pathology was often observed. Other sulfur amino acids interfere with this metabolism, i.e., l-cysteine (Cys) and N-aceyl-l-cysteine (NAC), and probably also affect cardiovascular system. Their effects are controversial due to their ability to act both as anti- or pro-oxidant. Thus, this study aimed to elucidate their influence on levels of homocysteine, folate and vitamin B12, levels of different haemostatic parameters (fibrinogen, D-dimer, vWF Ag, vWF Ac) in rat serum or plasma as well as their effects on cardiac and aortic tissue histology in subchronically methionine-treated rats. Wistar albino rats were divided into 4 experimental groups: (a) control group (0.9[%] sodium chloride 0.1–0.2 mL/day) (n = 10) (K); (b) dl-methionine (0.8 mmol/kg/bw/day) (n = 10) (M); (c) dl-methion
Ключевые слова:
Haemostasis; Heart; Homocysteine; Methionine; Sulfur amino acids
acetylcysteine; cyanocobalamin; cysteine; D dimer; fibrinogen; folic acid; homocysteine; methionine; sodium chloride; von Willebrand factor; acetylcysteine; biological marker; cysteine; hemostatic agent; homocysteine; methionine; amino acid metabolism; animal tissue; aortic tissue; Article; controlled study; high methionine diet; histology; hyperhomocysteinemia; male; nonhuman; rat; treatment duration; animal; aorta; cytology; drug effect; heart; metabolism; physiology; Wistar rat; Acetylcysteine; Animals; Aorta; Biomarkers; Cysteine; Heart; Hemostatics; Homocysteine; Male; Methionine; Rats; Rats, Wistar
Язык текста: Английский
ISSN: 1573-4919
Kostić S.
Mićovic Ž.
Andrejević L.
Cvetković S.
Stamenković A.
Stanković S.
Obrenović R.
Labudović-Borović M.
Hrnčić D.
Yakovlevich V. Vladimir 1971-
Djurić D.
Костиć С.
Миćовиc Ž.
Андрейевиć Л.
Cветковиć С.
Стаменковиć А.
Станковиć С.
Обреновиć Р.
Лабудовиć-Боровиć М.
Хрнčиć Д.
Яковлевич В. Владимир 1971-
Дйуриć Д.
The effects of l-cysteine and N-acetyl-l-cysteine on homocysteine metabolism and haemostatic markers, and on cardiac and aortic histology in subchronically methionine-treated Wistar male rats
The effects of l-cysteine and N-acetyl-l-cysteine on homocysteine metabolism and haemostatic markers, and on cardiac and aortic histology in...
Текст визуальный непосредственный
Molecular and Cellular Biochemistry
Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
Vol.451, Issue1-2 P. 43-54
2019
Статья
Haemostasis Heart Homocysteine Methionine Sulfur amino acids
acetylcysteine cyanocobalamin cysteine D dimer fibrinogen folic acid homocysteine methionine sodium chloride von Willebrand factor acetylcysteine biological marker cysteine hemostatic agent homocysteine methionine amino acid metabolism animal tissue aortic tissue Article controlled study high methionine diet histology hyperhomocysteinemia male nonhuman rat treatment duration animal aorta cytology drug effect heart metabolism physiology Wistar rat Acetylcysteine Animals Aorta Biomarkers Cysteine Heart Hemostatics Homocysteine Male Methionine Rats Rats, Wistar
Methionine is the precursor of homocysteine, a sulfur amino acid intermediate in the methylation and transsulfuration pathways; methionine-rich diets were used to induce hyperhomocysteinemia, and cardiovascular pathology was often observed. Other sulfur amino acids interfere with this metabolism, i.e., l-cysteine (Cys) and N-aceyl-l-cysteine (NAC), and probably also affect cardiovascular system. Their effects are controversial due to their ability to act both as anti- or pro-oxidant. Thus, this study aimed to elucidate their influence on levels of homocysteine, folate and vitamin B12, levels of different haemostatic parameters (fibrinogen, D-dimer, vWF Ag, vWF Ac) in rat serum or plasma as well as their effects on cardiac and aortic tissue histology in subchronically methionine-treated rats. Wistar albino rats were divided into 4 experimental groups: (a) control group (0.9[%] sodium chloride 0.1–0.2 mL/day) (n = 10) (K); (b) dl-methionine (0.8 mmol/kg/bw/day) (n = 10) (M); (c) dl-methion