Application of the HPLC/MS method for standartization of phenothiazine drugs
Шепочкина О. Y., Смирнов В. В., Прокофьева В. И., Грусчевскайа Л. Н., Пятин Б. М.
Биофармацевтический журнал
Т. 10, Вып. 2, С. 46-51
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Specific and reliable HPLC/MS methodology has been developed for the identification and assay of phenothiazine drugs. Aminazine, propazine, and fluphenazine were identified by the m/z values of the molecular ion formed in the process of ionization of substances and standard samples of phenothiazine drugs. The quantification limit of the procedure is 0.1 ng/mL for fluphenazine; 1.0 ng/mL, for propazine and aminazine. The procedure has been validated by the following characteristics: specificity, linearity, accuracy, and precision in accordance with SP XIII. © 2018, Folium Ltd. All rights reserved.
Ключевые слова:
Aminazine (chlorpromazine); Fluphenazine; HPLC/MS; Identification; Phenothiazine drugs; Propazinå (promazine); Validation
chlorpromazine; fluphenazine; phenothiazine; propazine; Article; ionization; limit of quantitation; liquid chromatography-mass spectrometry; measurement accuracy; measurement precision
Язык текста: Русский
ISSN: 2073-8099
Шепочкина О. Y.
Смирнов В. В. Валерий Валерьевич 1985-
Прокофьева В. И. Вера Ивановна 1945-
Грусчевскайа Л. Н.
Пятин Б. М.
Shepochkina O. Y.
Smirnov V. V. Valerij Valeryevich 1985-
Prokofyeva V. I. Vera Ivanovna 1945-
Gruschevskaja L. N.
Pyatin B. M.
Application of the HPLC/MS method for standartization of phenothiazine drugs
Текст визуальный непосредственный
Биофармацевтический журнал
ООО "Фолиум"
Т. 10, Вып. 2 С. 46-51
2018
Статья
Aminazine (chlorpromazine) Fluphenazine HPLC/MS Identification Phenothiazine drugs Propazinå (promazine) Validation
chlorpromazine fluphenazine phenothiazine propazine Article ionization limit of quantitation liquid chromatography-mass spectrometry measurement accuracy measurement precision
Specific and reliable HPLC/MS methodology has been developed for the identification and assay of phenothiazine drugs. Aminazine, propazine, and fluphenazine were identified by the m/z values of the molecular ion formed in the process of ionization of substances and standard samples of phenothiazine drugs. The quantification limit of the procedure is 0.1 ng/mL for fluphenazine; 1.0 ng/mL, for propazine and aminazine. The procedure has been validated by the following characteristics: specificity, linearity, accuracy, and precision in accordance with SP XIII. © 2018, Folium Ltd. All rights reserved.