The individual tailoring of immunosuppressive therapy after heart transplantation
Колоскова Н. Н., Попцов В. Н., Шевченко А. О.
Вестник трансплантологии и искусственных органов
Т. 20, Вып. 1, С. 127-137
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.15825/1995-1191-2018-1-127-137
Аннотация:
Heart transplantation is the gold standard of treatment severe heart failure. Immunosuppressive therapy aimed at the prevention of acute allograft rejection is the cornerstone of post-transplant management. In addition to its direct effects, immunosuppressive therapy is also involved in the generation of a number of post-transplant morbidities that limit the long-term outcome of heart transplant recipients. Given these data it appears that the individual tailoring of immunosuppressive therapy is of paramount importance in determining the outcome of heart transplantation. The goal of immunosuppressive therapy is to prevent rejection of the transplanted heart, while minimizing drug-related effects, such as infection, malignancy, diabetes, hypertension, and renal insuffi ciency. This review aimed is to analyze the protocols for the appointment of immunosuppressive therapy in various groups of recipients after heart transplantation. © 2018 Russian Transplant Society. All rights reserved.
Ключевые слова:
Cardiac recipient survival; Drug interaction; Heart transplantation; Immunosuppressive therapy
Язык текста: Русский
ISSN: 2412-6160
Колоскова Н. Н.
Попцов В. Н. Виталий Николаевич 0001-
Шевченко А. О. Алексей Олегович 1972-
Koloskova N. N.
Poptsov V. N. Vitalij Nikolaevich 0001-
Shevchenko A. O. Aleksej Olegovich 1972-
The individual tailoring of immunosuppressive therapy after heart transplantation
Текст визуальный непосредственный
Вестник трансплантологии и искусственных органов
Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова
Т. 20, Вып. 1 С. 127-137
2018
Обзор
Cardiac recipient survival Drug interaction Heart transplantation Immunosuppressive therapy
Heart transplantation is the gold standard of treatment severe heart failure. Immunosuppressive therapy aimed at the prevention of acute allograft rejection is the cornerstone of post-transplant management. In addition to its direct effects, immunosuppressive therapy is also involved in the generation of a number of post-transplant morbidities that limit the long-term outcome of heart transplant recipients. Given these data it appears that the individual tailoring of immunosuppressive therapy is of paramount importance in determining the outcome of heart transplantation. The goal of immunosuppressive therapy is to prevent rejection of the transplanted heart, while minimizing drug-related effects, such as infection, malignancy, diabetes, hypertension, and renal insuffi ciency. This review aimed is to analyze the protocols for the appointment of immunosuppressive therapy in various groups of recipients after heart transplantation. © 2018 Russian Transplant Society. All rights reserved.