Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages
Bochkareva S. S., Karaulov A. V., Aleshkin A. V., Novikova L. I., Kiseleva I. A., Rubal’skii E. O., Mekhtiev E. R., Styshnev A. O., Zul’karneev E. R., Anurova M. N., Bakhrushina E. O., Letarov A. V.
Bulletin of Experimental Biology and Medicine
Vol.168, Issue6, P. 748-752
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1007/s10517-020-04794-w
Аннотация:
Pharmacokinetics of suppository forms of bacteriophages was studied on male Chinchilla rabbits. Suppositories with various composition of bacteriophages were administered once per rectum to rabbits, and the presence of phage particles was estimated in the blood, urine, and feces over 24 h. Pharmacokinetic study showed that the phages were detected in the blood, urine, and feces at various terms of the experiment irrespective of the size of viral particles, which confirmed the possibility of their systemic effects after rectal administration. Thus, the use of suppository form of bacteriophages can ensure the presence of phage particles even in infection foci that cannot directly contact with the preparation. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
bacteriophages; pharmacokinetics; suppository; systemic effect
adult; animal experiment; animal tissue; article; bacteriophage; chinchilla rabbit; controlled study; feces; male; nonhuman; pharmacokinetics; rectal drug administration; suppository; virus particle
Язык текста: Английский
ISSN: 1573-8221
Bochkareva S. S.
Karaulov A. V. Aleksandr Viktorovich 1953-
Aleshkin A. V.
Novikova L. I.
Kiseleva I. A.
Rubal’skii E. O.
Mekhtiev E. R.
Styshnev A. O.
Zul’karneev E. R.
Anurova M. N. Mariya Nikolaevna 1981-
Bakhrushina E. O. Elena Olegovna 1991-
Letarov A. V.
Бочкарева С. С.
Караулов А. В. Александр Викторович 1953-
Алешкин А. В.
Новикова Л. И.
Киселева И. А.
Рубал’скии Е. О.
Мехтиев Е. Р.
Стyшнев А. О.
Зул’карнеев Е. Р.
Анурова М. Н. Мария Николаевна 1981-
Бахрушина Е. О. Елена Олеговна 1991-
Летаров А. В.
Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.168, Issue6 P. 748-752
2020
Статья
bacteriophages pharmacokinetics suppository systemic effect
adult animal experiment animal tissue article bacteriophage chinchilla rabbit controlled study feces male nonhuman pharmacokinetics rectal drug administration suppository virus particle
Pharmacokinetics of suppository forms of bacteriophages was studied on male Chinchilla rabbits. Suppositories with various composition of bacteriophages were administered once per rectum to rabbits, and the presence of phage particles was estimated in the blood, urine, and feces over 24 h. Pharmacokinetic study showed that the phages were detected in the blood, urine, and feces at various terms of the experiment irrespective of the size of viral particles, which confirmed the possibility of their systemic effects after rectal administration. Thus, the use of suppository form of bacteriophages can ensure the presence of phage particles even in infection foci that cannot directly contact with the preparation. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.