Аннотация:
Objective To evaluate and study the dynamics of endothelial dysfunction instrumental indicators, vascular wall stiffness and microcirculation state in patients with gastric cancer (adenocarcinoma) before and after chemotherapy; compare it with the results obtained from healthy volunteers and patients with cardiovascular diseases. Materials and Methods The study included 65 people: 25 healthy volunteers, 15 patients with known cardio-vascular diseases (CVD) and 25 patients with histologically confirmed gastric cancer (adenocarcinoma) stage 2-4 who underwent surgical treatment followed by chemotherapy according to the FOLFOX, XELOX, and XP regimes. For non-invasive assessment of the vascular wall's state of large vessels and microcirculation, all patients in the main group underwent computer nailfold capillaroscopy and finger photoplethysmography before chemotherapy and within a month after the completion of the last course. For healthy volunteers and patients with CVD, the above studies
Ключевые слова:
Chemotherapy; Computer nailfold capillaroscopy; Endothelial dysfunction; Gastric cancer; Microcirculation; Pulse-wave analysis
capecitabine; cisplatin; fluorouracil; oxaliplatin; adult; arterial smooth muscle; Article; blood vessel wall; cancer chemotherapy; cancer patient; capillaroscopy; capillary; cardiac patient; cardiovascular disease; controlled study; endothelial dysfunction; female; functional disease; human; hyperemia; major clinical study; male; microcirculation; middle aged; photoelectric plethysmography; pulse wave; rigidity; stomach cancer; angioscopy; arterial stiffness; microcirculation; stomach tumor; Capillaries; Humans; Microcirculation; Microscopic Angioscopy; Stomach Neoplasms; Vascular Stiffness
Kirichenko Y. Y. Yu.Yu.
Il`gisonis I. S. Irina Sergeevna 1983-
Belenkov Yu. N. Yurij Nikitich 1948-
Privalova E. V. Elena Vitalyevna 1958-
Naymann Yu. I. Yuliya Igorevna 1978-
Lyamin A. M. Aleksandr Mikhaylovich 1997-
Kozhevnikova M. V. Mariya Vladimirovna 1983-
Korobkova E. O.
Khabarova N. V. Natal`ya Vladimirovna 1964-
Ogorodnikov N. V.
Кириченко Y. Y. Ю.Ю.
Ильгисонис И. С. Ирина Сергеевна 1983-
Беленков Ю. Н. Юрий Никитич 1948-
Привалова Е. В. Елена Витальевна 1958-
Найманн Ю. И. Юлия Игоревна 1978-
Лямин А. М. Александр Михайлович 1997-
Кожевникова М. В. Мария Владимировна 1983-
Коробкова Е. О.
Хабарова Н. В. Наталья Владимировна 1964-
Огородников Н. В.
The effect of chemotherapy on endothelial function and microcirculation in patients with gastric cancer
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Vol.60, Issue2 P. 89-95
2020
Статья
Chemotherapy Computer nailfold capillaroscopy Endothelial dysfunction Gastric cancer Microcirculation Pulse-wave analysis
capecitabine cisplatin fluorouracil oxaliplatin adult arterial smooth muscle Article blood vessel wall cancer chemotherapy cancer patient capillaroscopy capillary cardiac patient cardiovascular disease controlled study endothelial dysfunction female functional disease human hyperemia major clinical study male microcirculation middle aged photoelectric plethysmography pulse wave rigidity stomach cancer angioscopy arterial stiffness microcirculation stomach tumor Capillaries Humans Microcirculation Microscopic Angioscopy Stomach Neoplasms Vascular Stiffness
Objective To evaluate and study the dynamics of endothelial dysfunction instrumental indicators, vascular wall stiffness and microcirculation state in patients with gastric cancer (adenocarcinoma) before and after chemotherapy; compare it with the results obtained from healthy volunteers and patients with cardiovascular diseases. Materials and Methods The study included 65 people: 25 healthy volunteers, 15 patients with known cardio-vascular diseases (CVD) and 25 patients with histologically confirmed gastric cancer (adenocarcinoma) stage 2-4 who underwent surgical treatment followed by chemotherapy according to the FOLFOX, XELOX, and XP regimes. For non-invasive assessment of the vascular wall's state of large vessels and microcirculation, all patients in the main group underwent computer nailfold capillaroscopy and finger photoplethysmography before chemotherapy and within a month after the completion of the last course. For healthy volunteers and patients with CVD, the above studies