The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration
Afferi L., Zamboni S., Karnes R. J., Roghmann F., Sargos P., Montorsi F., Briganti A., Gallina A., Mattei A., Schulz G. B., Hendricksen K., Voskuilen C. S., Rink M., Poyet C., De C. O., di T. E., Simeone C., Soligo M., Simone G., Tuderti G., Alvarez-Maestro M., Martínez-Piñeiro L., Aziz A., Shariat Sh., Abufaraj M., Xylinas E., Moschini M.
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1007/s00345-020-03205-z
Аннотация:
Purpose: To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status. Methods: A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral centers from 1990 to 2017. Selected cN+ patients received induction chemotherapy (IC), whereas adjuvant chemotherapy (ACT) was delivered to selected pN+ patients. Univariable and multivariable Cox regression analyses were used to predict overall mortality (OM) after surgery, adjusting for clinicopathological confounders. Kaplan–Meier analyses assessed OM according to the treatment modality. Results: Overall, 356 (56[%]) patients were treated with surgery alone, 155 (24[%]) with IC followed by surgery, and 128 (20[%]) with ACT following surgery. Over a median follow-up of 25 months, 316 deaths were recorded. At univariable analy
Ключевые слова:
Bladder cancer; Clinical metastases; Induction chemotherapy; Multimodal treatment; Radical cystectomy; Urothelial cancer
Язык текста: Английский
ISSN: 1433-8726
Afferi L.
Zamboni S.
Karnes R. J.
Roghmann F.
Sargos P.
Montorsi F.
Briganti A.
Gallina A.
Mattei A.
Schulz G. B.
Hendricksen K.
Voskuilen C. S.
Rink M.
Poyet C.
De C. O. Cobelli O.
di T. E. Trapani E.
Simeone C.
Soligo M.
Simone G.
Tuderti G.
Alvarez-Maestro M.
Martínez-Piñeiro L.
Aziz A.
Shariat Sh. Sharokh 1973-
Abufaraj M.
Xylinas E.
Moschini M.
Аффери Л.
Замбони С.
Карнес Р. Й.
Рогхманн Ф.
Саргос П.
Монторси Ф.
Бриганти А.
Галлина А.
Маттеи А.
Счулз Г. Б.
Хендриcксен К.
Воскуилен C. С.
Ринк М.
Поьет C.
Де C. О. Cобелли О.
ди Т. Е. Трапани Е.
Симеоне C.
Солиго М.
Симоне Г.
Тюдерти Г.
Алварез-Маестро М.
Мартíнез-Пиñеиро Л.
Азиз А.
Шариат Ш. Шарох 1973-
Абуфарай М.
Хyлинас Е.
Мосчини М.
The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration
Текст визуальный непосредственный
World Journal of Urology
Springer-Verlag GmbH
Статья
Bladder cancer Clinical metastases Induction chemotherapy Multimodal treatment Radical cystectomy Urothelial cancer
Purpose: To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status. Methods: A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral centers from 1990 to 2017. Selected cN+ patients received induction chemotherapy (IC), whereas adjuvant chemotherapy (ACT) was delivered to selected pN+ patients. Univariable and multivariable Cox regression analyses were used to predict overall mortality (OM) after surgery, adjusting for clinicopathological confounders. Kaplan–Meier analyses assessed OM according to the treatment modality. Results: Overall, 356 (56[%]) patients were treated with surgery alone, 155 (24[%]) with IC followed by surgery, and 128 (20[%]) with ACT following surgery. Over a median follow-up of 25 months, 316 deaths were recorded. At univariable analy