Cerebrovascular disorders and glucolipotoxicity [Цереброваскулярные заболевания и глюколипотоксичность]
Танашян М. М., Антонова К. В., Раскуражев А. А., Лагода О. В., Шабалина А. А., Романцова Т. И.
Анналы клинической и экспериментальной неврологии
Т. 14, Вып. 1, С. 17-24
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.25692/ACEN.2020.1.2
Аннотация:
Introduction: Rapid progression of atherosclerosis and, consequently, an increase in the risk of stroke and myocardial infarction are associated with the presence of diabetes mellitus (DM). There is a search for new biomarkers of these pathological conditions, including their preclinical forms, primarily associated with insulin resistance (IR), which underlies these metabolic disorders. Development of the glucose and lipid toxicity is considered as one of the decisive factors in the development of IR and atherosclerotic cardiovascular disease in the presence of disturbances in carbohydrate and lipid metabolism. The negative consequences of isolated glucose- and/or lipid toxicity are less than the presence of both conditions simultaneously, known as glucolipotoxicity. The triglyceride glucose (TyG) index, initially developed to assess such combined changes, is of great interest to researchers as a marker or predictor of diseases associated with IR. Aim: to investigate the effect of gluc
Ключевые слова:
Atherosclerosis; Diabetes mellitus; Glucolipotoxicity; Stroke; Triglyceride glucose index
Язык текста: Русский
ISSN: 2409-2533
Танашян М. М.
Антонова К. В.
Раскуражев А. А.
Лагода О. В.
Шабалина А. А.
Романцова Т. И. Татьяна Ивановна 1959-
Tanashyan M. M.
Antonova K. V.
Raskurazhev A. A.
Lagoda O. V.
Shabalina A. A.
Romantsova T. I. Tat`yana Ivanovna 1959-
Cerebrovascular disorders and glucolipotoxicity [Цереброваскулярные заболевания и глюколипотоксичность]
Текст визуальный непосредственный
Анналы клинической и экспериментальной неврологии
РКИ Соверо пресс
Т. 14, Вып. 1 С. 17-24
2020
Статья
Atherosclerosis Diabetes mellitus Glucolipotoxicity Stroke Triglyceride glucose index
Introduction: Rapid progression of atherosclerosis and, consequently, an increase in the risk of stroke and myocardial infarction are associated with the presence of diabetes mellitus (DM). There is a search for new biomarkers of these pathological conditions, including their preclinical forms, primarily associated with insulin resistance (IR), which underlies these metabolic disorders. Development of the glucose and lipid toxicity is considered as one of the decisive factors in the development of IR and atherosclerotic cardiovascular disease in the presence of disturbances in carbohydrate and lipid metabolism. The negative consequences of isolated glucose- and/or lipid toxicity are less than the presence of both conditions simultaneously, known as glucolipotoxicity. The triglyceride glucose (TyG) index, initially developed to assess such combined changes, is of great interest to researchers as a marker or predictor of diseases associated with IR. Aim: to investigate the effect of gluc