Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish
Wang D., Yang L., Wang J., Hu G., Liu Z., Yan D., Serikuly N., Alpyshov E. T., Demin K. A., Galstyan D. S., Strekalova T. V., de A. M. S., Amstislavskaya T. G., Kalueff A. V.
Neurotoxicology and Teratology
Vol.79, Num.106881
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1016/j.ntt.2020.106881
Аннотация:
Kava kava (Piper methysticum) is a medicinal plant containing kavalactones that exert potent sedative, analgesic and anti-stress action. However, their pharmacological effects and molecular targets remain poorly understood. The zebrafish (Danio rerio) has recently emerged as a powerful new model organism for neuroscience research and drug discovery. Here, we evaluate the effects of acute and chronic exposure to kava and kavalactones on adult zebrafish anxiety, aggression and sociality, as well as on their neurochemical, neuroendocrine and genomic responses. Supporting evolutionarily conserved molecular targets, acute kava and kavalactones evoked dose-dependent behavioral inhibition, upregulated brain expression of early protooncogenes c-fos and c-jun, elevated brain monoamines and lowered whole-body cortisol. Chronic 7-day kava exposure evoked similar behavioral effects, did not alter cortisol levels, and failed to evoke withdrawal-like states upon discontinuation. However, chronic kav
Ключевые слова:
Behavior; Cortisol; Kava; Monoamines; Neuroglia; Zebrafish
CD11b antigen; CD206 antigen; complement component C3; complement component C4b; early growth response factor 2; hydrocortisone; inducible nitric oxide synthase; interleukin 1beta; interleukin 4; interleukin 6; kava; kavalactone; lactone derivative; lymphocyte antigen; monoamine; plant medicinal product; protein S 100; protein S100A; steroid receptor coactivator 1; tumor necrosis factor; unclassified drug; adult; aggression; animal behavior; animal cell; animal experiment; anxiety; apoptosis; Article; astrocyte; behavior; behavioral inhibition; brain level; cohort analysis; concentration response; controlled study; down regulation; drug exposure; drug mechanism; drug targeting; epigenetics; female; gene expression regulation; genetic conservation; genomics; inflammation; long term exposure; male; microglia; neurochemistry; nonhuman; oncogene c fos; oncogene c jun; physiological process; Piper methysticum; priority journal; social behavior; upregulation; withdrawal syndrome; zebra fish
Язык текста: Английский
ISSN: 1872-9738
Wang D.
Yang L.
Wang J.
Hu G.
Liu Z.
Yan D.
Serikuly N.
Alpyshov E. T.
Demin K. A.
Galstyan D. S.
Strekalova T. V. Tat`yana Valeryevna 1969-
de A. M. S. Abreu M.S.
Amstislavskaya T. G.
Kalueff A. V.
Wанг Д.
Янг Л.
Wанг Й.
Ху Г.
Лиу З.
Ян Д.
Серикулy Н.
Алпyшов Е. Т.
Демин К. А.
Галстян Д. С.
Стрекалова Т. В. Татьяна Валерьевна 1969-
де А. М. С. Абреу М.С.
Амстиславскайа Т. Г.
Калуефф А. В.
Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish
Текст визуальный непосредственный
Neurotoxicology and Teratology
Elsevier Science Publisher B.V.
Vol.79 Num.106881
2020
Статья
Behavior Cortisol Kava Monoamines Neuroglia Zebrafish
CD11b antigen CD206 antigen complement component C3 complement component C4b early growth response factor 2 hydrocortisone inducible nitric oxide synthase interleukin 1beta interleukin 4 interleukin 6 kava kavalactone lactone derivative lymphocyte antigen monoamine plant medicinal product protein S 100 protein S100A steroid receptor coactivator 1 tumor necrosis factor unclassified drug adult aggression animal behavior animal cell animal experiment anxiety apoptosis Article astrocyte behavior behavioral inhibition brain level cohort analysis concentration response controlled study down regulation drug exposure drug mechanism drug targeting epigenetics female gene expression regulation genetic conservation genomics inflammation long term exposure male microglia neurochemistry nonhuman oncogene c fos oncogene c jun physiological process Piper methysticum priority journal social behavior upregulation withdrawal syndrome zebra fish
Kava kava (Piper methysticum) is a medicinal plant containing kavalactones that exert potent sedative, analgesic and anti-stress action. However, their pharmacological effects and molecular targets remain poorly understood. The zebrafish (Danio rerio) has recently emerged as a powerful new model organism for neuroscience research and drug discovery. Here, we evaluate the effects of acute and chronic exposure to kava and kavalactones on adult zebrafish anxiety, aggression and sociality, as well as on their neurochemical, neuroendocrine and genomic responses. Supporting evolutionarily conserved molecular targets, acute kava and kavalactones evoked dose-dependent behavioral inhibition, upregulated brain expression of early protooncogenes c-fos and c-jun, elevated brain monoamines and lowered whole-body cortisol. Chronic 7-day kava exposure evoked similar behavioral effects, did not alter cortisol levels, and failed to evoke withdrawal-like states upon discontinuation. However, chronic kav