Dose-Dependent Clinical, Radiographic, and Histopathologic Changes of 17β-Estradiol Levels Within the Temporomandibular Joint: An Experimental...
Abdel H. M. A., Hassan E. A., Zaied A. A., Amaroli A., Sorour N. H.
Journal of Oral and Maxillofacial Surgery
Vol.78, Issue8, P. 1304-1313
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1016/j.joms.2020.03.014
Аннотация:
Purpose: The aim of this study was to test the hypothesis that the dose of estrogen replacement therapy may have an influence on the clinical, radiographic, and histopathologic changes within the temporomandibular joint (TMJ). Materials and Methods: A prospective experimental study was conducted in 12 mature ovariectomized dogs. Dogs were randomly allocated into 1 of 4 groups (OVX-E0, dogs that did not receive any estrogen replacement therapy; OVX-E0.5, dogs that received 0.15 mg/kg of estradiol; OVX-E1, dogs that received 0.3 mg/kg of estradiol; and OVX-E2, dogs that received 0.6 mg/kg of estradiol); dogs were evaluated clinically for 12 weeks; and contact radiographic and histopathologic examinations of the TMJ were performed just after euthanasia. Results: Radiographic examination of the TMJ in the OVX-E0 group showed narrowing of the joint space with marginal osteophyte formation along the mandibular condyle. The OVX-E0.5 group showed mild widening of the joint space with no remark
Ключевые слова:
collagen type 1; collagen type 3; diethylstilbestrol; estradiol; estradiol; estrogen; animal euthanasia; animal experiment; animal tissue; Article; bone tissue; canine model; collagen fiber; controlled study; dental surgeon; dose response; drug megadose; estradiol blood level; estrogen therapy; experimental study; female; Haversian canal; histopathology; joint cavity; joint radiography; mandible condyle; mongrel dog; nonhuman; osteocyte; osteolysis; osteophyte; osteosclerosis; ovariectomy; prospective study; subchondral bone; temporomandibular joint; trabecular bone; trabecular thickness; animal; diagnostic imaging; dog; human; temporomandibular joint; Animals; Dogs; Estradiol; Estrogens; Female; Humans; Ovariectomy; Prospective Studies; Temporomandibular Joint
Язык текста: Английский
ISSN: 1531-5053
Abdel H. M. A. Hamid M.A.
Hassan E. A.
Zaied A. A.
Amaroli A. Andrea 1971-
Sorour N. H.
Абдел Х. М. А. Хамид М.А.
Хассан Е. А.
Заиед А. А.
Амароли А. Андреа 1971-
Сороур Н. Х.
Dose-Dependent Clinical, Radiographic, and Histopathologic Changes of 17β-Estradiol Levels Within the Temporomandibular Joint: An Experimental Study in Ovariectomized Dogs
Dose-Dependent Clinical, Radiographic, and Histopathologic Changes of 17β-Estradiol Levels Within the Temporomandibular Joint: An Experimental...
Текст визуальный непосредственный
Journal of Oral and Maxillofacial Surgery
W.B. Saunders
Vol.78, Issue8 P. 1304-1313
2020
Статья
collagen type 1 collagen type 3 diethylstilbestrol estradiol estradiol estrogen animal euthanasia animal experiment animal tissue Article bone tissue canine model collagen fiber controlled study dental surgeon dose response drug megadose estradiol blood level estrogen therapy experimental study female Haversian canal histopathology joint cavity joint radiography mandible condyle mongrel dog nonhuman osteocyte osteolysis osteophyte osteosclerosis ovariectomy prospective study subchondral bone temporomandibular joint trabecular bone trabecular thickness animal diagnostic imaging dog human temporomandibular joint Animals Dogs Estradiol Estrogens Female Humans Ovariectomy Prospective Studies Temporomandibular Joint
Purpose: The aim of this study was to test the hypothesis that the dose of estrogen replacement therapy may have an influence on the clinical, radiographic, and histopathologic changes within the temporomandibular joint (TMJ). Materials and Methods: A prospective experimental study was conducted in 12 mature ovariectomized dogs. Dogs were randomly allocated into 1 of 4 groups (OVX-E0, dogs that did not receive any estrogen replacement therapy; OVX-E0.5, dogs that received 0.15 mg/kg of estradiol; OVX-E1, dogs that received 0.3 mg/kg of estradiol; and OVX-E2, dogs that received 0.6 mg/kg of estradiol); dogs were evaluated clinically for 12 weeks; and contact radiographic and histopathologic examinations of the TMJ were performed just after euthanasia. Results: Radiographic examination of the TMJ in the OVX-E0 group showed narrowing of the joint space with marginal osteophyte formation along the mandibular condyle. The OVX-E0.5 group showed mild widening of the joint space with no remark