Analysis of pregnancy and childbirth in women with multiple sclerosis: A prospective study

Introduction: Family planning for patients with multiple sclerosis (MS) raises many questions and requires an integrated approach from neurologists and obstetrician-gynaecologists. The study aimed: to define possible features of pregnancy and childbirth in patients with MS. Materials and methods: 204 patients with definite moderate MS, who were planning a pregnancy and taking First-Line Disease-Modifying Therapies (DMTs) before pregnancy. First group included 94 patients with pregnancies; the second group consisted of 110 patients, who failed to conceive within a stated period of time; in the third group there were 50 healthy women with normal pregnancies. Probability of developing pregnancy complications, time and method of delivery, anaesthetic procedures, weight, and height of newborns were assessed, while in the groups of patients with MS the risk of exacerbations and severity of the complications were evaluated. Results and discussion: In the first group, there were more frequent