The effect of polymorphisms c677t and А1298С gene mthfr on the reproductive function of men
Кулченко Н. Г., Мяндина Г. И., Алхейой Х., Тарасенко Е. В.
Урология
Т. 2020, Вып. 2, С. 66-70
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.18565/urology.2020.2.66-70
Аннотация:
References. Disturbances of spermogram parameters are associated with infertility in men and are determined by polymorphisms of many genes involved in spermatogenesis. Folate metabolism plays an important role in spermatogenesis, as it is involved in the synthesis, repair and methylation of DNA. Objective: the distribution of C677T (rs1801133) and A1298C (rs1801131) polymorphisms of the MTHFR gene among infertile and fertile men in the Moscow region and to identify a possible Association of these polymorphisms with the risk of pathospermia. Materials and methods: the study included 127 infertile men with different forms of pathospermia and 68 fertile men (with one or more children). Genotyping of polymorphisms (C677T and A1298C) gene MTHFR was performed by real-time polymerase chain reaction (PCR-RV). Results. Analysis of the distribution of MTHFR genotypes (C677T and A1298C) revealed no significant differences in the distribution of genotypes in groups of infertile and fertile men. Th
Ключевые слова:
Genetic factor; Male infertility; MTHFR; Polymorphism; The genes of folate metabolism
methylenetetrahydrofolate reductase (NADPH2); MTHFR protein, human; case control study; child; gene frequency; genetic predisposition; genetics; genotype; human; male; Russian Federation; single nucleotide polymorphism; Case-Control Studies; Child; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Moscow; Polymorphism, Single Nucleotide
Язык текста: Русский
ISSN: 1728-2985
Кулченко Н. Г.
Мяндина Г. И.
Алхейой Х.
Тарасенко Е. В.
Kulchenko N. G.
Myandina G. I.
Alhejoj H.
Tarasenko E. V.
The effect of polymorphisms c677t and А1298С gene mthfr on the reproductive function of men
Текст визуальный непосредственный
Урология
Бионика Медиа
Т. 2020, Вып. 2 С. 66-70
2020
Статья
Genetic factor Male infertility MTHFR Polymorphism The genes of folate metabolism
methylenetetrahydrofolate reductase (NADPH2) MTHFR protein, human case control study child gene frequency genetic predisposition genetics genotype human male Russian Federation single nucleotide polymorphism Case-Control Studies Child Gene Frequency Genetic Predisposition to Disease Genotype Humans Male Methylenetetrahydrofolate Reductase (NADPH2) Moscow Polymorphism, Single Nucleotide
References. Disturbances of spermogram parameters are associated with infertility in men and are determined by polymorphisms of many genes involved in spermatogenesis. Folate metabolism plays an important role in spermatogenesis, as it is involved in the synthesis, repair and methylation of DNA. Objective: the distribution of C677T (rs1801133) and A1298C (rs1801131) polymorphisms of the MTHFR gene among infertile and fertile men in the Moscow region and to identify a possible Association of these polymorphisms with the risk of pathospermia. Materials and methods: the study included 127 infertile men with different forms of pathospermia and 68 fertile men (with one or more children). Genotyping of polymorphisms (C677T and A1298C) gene MTHFR was performed by real-time polymerase chain reaction (PCR-RV). Results. Analysis of the distribution of MTHFR genotypes (C677T and A1298C) revealed no significant differences in the distribution of genotypes in groups of infertile and fertile men. Th