The impact of transcription factor prospero homeobox 1 on the regulation of thyroid cancer malignancy
Rudzhin`ska M., Czarnocka B.
International Journal of Molecular Sciences
Vol.21, Issue9, Num.3220
Опубликовано: 2020
Тип ресурса: Обзор
Аннотация:
Transcription factor Prospero homeobox 1 (PROX1) is continuously expressed in the lymphatic endothelial cells, playing an essential role in their differentiation. Many reports have shown that PROX1 is implicated in cancer development and acts as an oncoprotein or suppressor in a tissue-dependent manner. Additionally, the PROX1 expression in many types of tumors has prognostic significance and is associated with patient outcomes. In our previous experimental studies, we showed that PROX1 is present in the thyroid cancer (THC) cells of different origins and has a high impact on follicular thyroid cancer (FTC) phenotypes, regulating migration, invasion, focal adhesion, cytoskeleton reorganization, and angiogenesis. Herein, we discuss the PROX1 transcript and protein structures, the expression pattern of PROX1 in THC specimens, and its epigenetic regulation. Next, we emphasize the biological processes and genes regulated by PROX1 in CGTH-W-1 cells, derived from squamous cell carcinoma of t
Ключевые слова:
Lymphatic factors; PROX1; Thyroid cancers
B Raf kinase; DNA methyltransferase; isoprotein; long untranslated RNA; messenger RNA; peroxisome proliferator activated receptor; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; prospero homeobox 1; protein p53; RNA polymerase II; telomerase reverse transcriptase; thyrotropin; transcription factor; unclassified drug; vasculotropin; 3' untranslated region; angiogenesis; apoptosis; carcinogenesis; cell migration; cell proliferation; cell survival; colony formation; cytoskeleton; disease severity; DNA methylation; down regulation; epigenetics; epithelial mesenchymal transition; gene control; gene expression; gene mutation; genetic regulation; human; lobectomy; lymphangiogenesis; MAPK signaling; nonhuman; protein expression; Review; RNA editing; RNA interference; signal transduction; single nucleotide polymorphism; squamous cell carcinoma; thyroid adenoma; thyroid cancer; thyroid papillary carcinoma; thyroidectomy; tumor growth; tumor suppressor gene; ubiquitination; upregulation
Язык текста: Английский
ISSN: 1661-6596
Rudzhin`ska M. Magdalena 1986-
Czarnocka B.
Руджиньска М. Магдалена 1986-
Cзарноcка Б.
The impact of transcription factor prospero homeobox 1 on the regulation of thyroid cancer malignancy
Текст визуальный непосредственный
International Journal of Molecular Sciences
Vol.21, Issue9 Num.3220
2020
Обзор
Lymphatic factors PROX1 Thyroid cancers
B Raf kinase DNA methyltransferase isoprotein long untranslated RNA messenger RNA peroxisome proliferator activated receptor phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase prospero homeobox 1 protein p53 RNA polymerase II telomerase reverse transcriptase thyrotropin transcription factor unclassified drug vasculotropin 3' untranslated region angiogenesis apoptosis carcinogenesis cell migration cell proliferation cell survival colony formation cytoskeleton disease severity DNA methylation down regulation epigenetics epithelial mesenchymal transition gene control gene expression gene mutation genetic regulation human lobectomy lymphangiogenesis MAPK signaling nonhuman protein expression Review RNA editing RNA interference signal transduction single nucleotide polymorphism squamous cell carcinoma thyroid adenoma thyroid cancer thyroid papillary carcinoma thyroidectomy tumor growth tumor suppressor gene ubiquitination upregulation
Transcription factor Prospero homeobox 1 (PROX1) is continuously expressed in the lymphatic endothelial cells, playing an essential role in their differentiation. Many reports have shown that PROX1 is implicated in cancer development and acts as an oncoprotein or suppressor in a tissue-dependent manner. Additionally, the PROX1 expression in many types of tumors has prognostic significance and is associated with patient outcomes. In our previous experimental studies, we showed that PROX1 is present in the thyroid cancer (THC) cells of different origins and has a high impact on follicular thyroid cancer (FTC) phenotypes, regulating migration, invasion, focal adhesion, cytoskeleton reorganization, and angiogenesis. Herein, we discuss the PROX1 transcript and protein structures, the expression pattern of PROX1 in THC specimens, and its epigenetic regulation. Next, we emphasize the biological processes and genes regulated by PROX1 in CGTH-W-1 cells, derived from squamous cell carcinoma of t