Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma
Behtaj S., Öchsner A., Anissimov Yu. G., Rybachuk M.
Tissue Engineering and Regenerative Medicine
Vol.17, Issue3, P. 253-269
Опубликовано: 2020
Тип ресурса: Обзор
DOI:10.1007/s13770-020-00254-8
Аннотация:
Background:: Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of blindness worldwide. As an optic neuropathy, glaucoma is identified by increasing degeneration of retinal ganglion cells (RGCs), with consequential vision loss. Current treatments only postpone the development of retinal degeneration, and there are as yet no treatments available for this disability. Recent studies have shown that replacing lost or damaged RGCs with healthy RGCs or RGC precursors, supported by appropriately designed bio-material scaffolds, could facilitate the development and enhancement of connections to ganglion cells and optic nerve axons. The consequence may be an improved retinal regeneration. This technique could also offer the possibility for retinal regeneration in treating other forms of optic nerve ailments through RGC replacement. Methods:: In this brief review, we describe the
Ключевые слова:
Biomaterials; Cell therapy; Glaucoma; Retinal ganglion cells; Tissue engineering
Cell engineering; Cytology; Eye protection; Gene therapy; Scaffolds (biology); Tissue; Vision; Current treatments; Functional integration; Immune response; Optic neuropathies; Retinal degenerations; Retinal ganglion cells; Tissue-engineered scaffolds; Visual functions; Ophthalmology; adrenergic receptor stimulating agent; beta adrenergic receptor blocking agent; carbonate dehydratase inhibitor; cholinergic receptor stimulating agent; prostaglandin derivative; biocompatibility; bioengineering; blindness; cell survival; cell transplantation; closed angle glaucoma; glaucoma; human; immune response; integration; intraocular pressure; nerve fiber; neuroprotection; nonhuman; open angle glaucoma; optic nerve; organoid; pathogenesis; priority journal; quality of life; regenerative medicine; retina cell; retina ganglion cell; retina tissue; retinal nerve fiber layer; Review; risk assessment; risk factor; vision
Язык текста: Английский
ISSN: 2212-5469
Behtaj S.
Öchsner A.
Anissimov Yu. G. Yurij German 1965-
Rybachuk M.
Бехтай С.
Öчснер А.
Аниссимов Ю. Г. Юрий Герман 1965-
Рyбачук М.
Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma
Текст визуальный непосредственный
Tissue Engineering and Regenerative Medicine
Vol.17, Issue3 P. 253-269
2020
Обзор
Biomaterials Cell therapy Glaucoma Retinal ganglion cells Tissue engineering
Cell engineering Cytology Eye protection Gene therapy Scaffolds (biology) Tissue Vision Current treatments Functional integration Immune response Optic neuropathies Retinal degenerations Retinal ganglion cells Tissue-engineered scaffolds Visual functions Ophthalmology adrenergic receptor stimulating agent beta adrenergic receptor blocking agent carbonate dehydratase inhibitor cholinergic receptor stimulating agent prostaglandin derivative biocompatibility bioengineering blindness cell survival cell transplantation closed angle glaucoma glaucoma human immune response integration intraocular pressure nerve fiber neuroprotection nonhuman open angle glaucoma optic nerve organoid pathogenesis priority journal quality of life regenerative medicine retina cell retina ganglion cell retina tissue retinal nerve fiber layer Review risk assessment risk factor vision
Background:: Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of blindness worldwide. As an optic neuropathy, glaucoma is identified by increasing degeneration of retinal ganglion cells (RGCs), with consequential vision loss. Current treatments only postpone the development of retinal degeneration, and there are as yet no treatments available for this disability. Recent studies have shown that replacing lost or damaged RGCs with healthy RGCs or RGC precursors, supported by appropriately designed bio-material scaffolds, could facilitate the development and enhancement of connections to ganglion cells and optic nerve axons. The consequence may be an improved retinal regeneration. This technique could also offer the possibility for retinal regeneration in treating other forms of optic nerve ailments through RGC replacement. Methods:: In this brief review, we describe the