Microbiome Composition and Its Impact on the Development of Allergic Diseases
Peroni D. G., Nuzzi G., Trambusti I., Di C. M. E., Komber`yati P.
Frontiers in Immunology
Vol.11, Num.700
Опубликовано: 2020
Тип ресурса: Обзор
DOI:10.3389/fimmu.2020.00700
Аннотация:
Allergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported over the last few years has closely paralleled substantial environmental changes both on a macro and micro scale, which have led to reduced microbial exposure in early life and perturbation of the human microbiome composition. Increasing evidence shows that early life interactions between the human microbiome and the immune cells play a pivotal role in the development of the immune system. Therefore, the process of early colonization by a “healthy” microbiome is emerging as a key determinant of life-long health. In stark contrast, the perturbation of such a process, which results in changes in the host-microbiome biodiversity and metabolic activities, has been associated with greater suscepti
Ключевые слова:
allergy; asthma; atopic dermatitis; children; food allergy; health outcomes; immune system; microbiome
Actinobacteria; allergic disease; asthma; atopic dermatitis; Bacteroides; Bifidobacterium; Bifidobacterium animalis; biodiversity; breast feeding; Citrobacter; Clostridioides difficile; Clostridium; complementary feeding; Enterobacter; Enterococcus; Faecalibacterium prausnitzii; Firmicutes; food allergy; human; immune response; immune system; immunogenicity; immunoregulation; immunotherapy; innate immunity; Klebsiella; Lachnospiraceae; Lactobacillus; Lactobacillus casei; microbial colonization; microbial diversity; microbiome; nonhuman; oral immunotherapy; prevalence; Prevotella; Proteobacteria; Review; Ruminococcaceae; Staphylococcus aureus; Staphylococcus epidermidis; Verrucomicrobia
Язык текста: Английский
ISSN: 1664-3224
Peroni D. G.
Nuzzi G.
Trambusti I.
Di C. M. E. Cicco M.E.
Komber`yati P. Paskuale 1988-
Перони Д. Г.
Нуззи Г.
Трамбусти И.
Ди C. М. Е. Cиccо М.Е.
Комберьяти П. Паскуале 1988-
Microbiome Composition and Its Impact on the Development of Allergic Diseases
Текст визуальный непосредственный
Frontiers in Immunology
Vol.11 Num.700
2020
Обзор
allergy asthma atopic dermatitis children food allergy health outcomes immune system microbiome
Actinobacteria allergic disease asthma atopic dermatitis Bacteroides Bifidobacterium Bifidobacterium animalis biodiversity breast feeding Citrobacter Clostridioides difficile Clostridium complementary feeding Enterobacter Enterococcus Faecalibacterium prausnitzii Firmicutes food allergy human immune response immune system immunogenicity immunoregulation immunotherapy innate immunity Klebsiella Lachnospiraceae Lactobacillus Lactobacillus casei microbial colonization microbial diversity microbiome nonhuman oral immunotherapy prevalence Prevotella Proteobacteria Review Ruminococcaceae Staphylococcus aureus Staphylococcus epidermidis Verrucomicrobia
Allergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported over the last few years has closely paralleled substantial environmental changes both on a macro and micro scale, which have led to reduced microbial exposure in early life and perturbation of the human microbiome composition. Increasing evidence shows that early life interactions between the human microbiome and the immune cells play a pivotal role in the development of the immune system. Therefore, the process of early colonization by a “healthy” microbiome is emerging as a key determinant of life-long health. In stark contrast, the perturbation of such a process, which results in changes in the host-microbiome biodiversity and metabolic activities, has been associated with greater suscepti