Аннотация:
In view of the emerging COVID' 19 pandemic caused by SARS'C oV'2 virus, the search for potential protective and therapeutic antiviral strategies is of particular and urgent interest. Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Despite the lack of clinical data, certain indications suggest that modulation of zinc status may be beneficial in COVID'19. In vitro experiments demonstrate that Zn2+ possesses antiviral activity through inhibition of SARS'C oV RNA polymerase. This effect may underlie therapeutic efficiency of chloroquine known to act as zinc ionophore. Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin'converting enzyme 2 (ACE2), known to be the receptor for SARS'C oV'2. Improved antiviral immunity by zinc may also occur through up'regulation of interferon α production and increasing its antiviral activity. Zinc possesses anti'inflammatory activity by inhibiting NF'κB signaling and modulatio
Ключевые слова:
Coronavirus; Immunity; Pneumonia; SARS'C oV'2; Zinc
alpha interferon; angiotensin converting enzyme 2; claudin 1; CXCL1 chemokine; gluconate zinc; I kappa B kinase beta; immunoglobulin enhancer binding protein; intercellular adhesion molecule 1; interleukin 1beta; interleukin 23; interleukin 6; interleukin 8; Janus kinase 1; messenger RNA; mitogen activated protein kinase 1; mitogen activated protein kinase 3; Pneumococcus vaccine; protein ZO1; Raf protein; STAT1 protein; transcription factor RelA; tumor necrosis factor; unclassified drug; zinc acetate; zinc ion; zinc oxide nanoparticle; zinc transporter; ZIP8 protein; aging; antibacterial activity; antiinflammatory activity; antioxidant activity; antiviral activity; atherosclerosis; bronchiolitis; bronchitis; coronavirus disease 2019; cytokine production; diabetes mellitus; disease association; disease duration; disease predisposition; disease severity; down regulation; enzyme activity; enzyme inhibition; enzyme regulation; epithelium cell; fibrosing alveolitis; human; immune deficienc
Skal`ny'j A. V. Anatolij Viktorovich 1962-
Rink L.
Aysuvakova O. P. Ol`ga Pavlovna 1982-
Ashner M. Mikhae`l` 1955-
Gritsenko V. A.
Alekseenko S. I.
Svistunov A. A. Andrej Alekseevich 1965-
Petrakis D.
Spandidos D. A.
Oset Ya. U. Yan Ulav 1943-
Tsatsakis A. Aristidis 1957-
Tin`kov A. A. Aleksej Alekseevich 1989-
Скальный А. В. Анатолий Викторович 1962-
Ринк Л.
Айсувакова О. П. Ольга Павловна 1982-
Ашнер М. Михаэль 1955-
Гриценко В. А.
Алексеенко С. И.
Свистунов А. А. Андрей Алексеевич 1965-
Петракис Д.
Спандидос Д. А.
Осет Я. У. Ян Улав 1943-
Цацакис А. Аристидис 1957-
Тиньков А. А. Алексей Алексеевич 1989-
Zinc and respiratory tract infections: Perspectives for CoviD'19 (Review)
Текст визуальный непосредственный
International journal of molecular medicine
Spandidos Publications Ltd.
Vol.46, Issue1 P. 17-26
2020
Обзор
Coronavirus Immunity Pneumonia SARS'C oV'2 Zinc
alpha interferon angiotensin converting enzyme 2 claudin 1 CXCL1 chemokine gluconate zinc I kappa B kinase beta immunoglobulin enhancer binding protein intercellular adhesion molecule 1 interleukin 1beta interleukin 23 interleukin 6 interleukin 8 Janus kinase 1 messenger RNA mitogen activated protein kinase 1 mitogen activated protein kinase 3 Pneumococcus vaccine protein ZO1 Raf protein STAT1 protein transcription factor RelA tumor necrosis factor unclassified drug zinc acetate zinc ion zinc oxide nanoparticle zinc transporter ZIP8 protein aging antibacterial activity antiinflammatory activity antioxidant activity antiviral activity atherosclerosis bronchiolitis bronchitis coronavirus disease 2019 cytokine production diabetes mellitus disease association disease duration disease predisposition disease severity down regulation enzyme activity enzyme inhibition enzyme regulation epithelium cell fibrosing alveolitis human immune deficienc
In view of the emerging COVID' 19 pandemic caused by SARS'C oV'2 virus, the search for potential protective and therapeutic antiviral strategies is of particular and urgent interest. Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Despite the lack of clinical data, certain indications suggest that modulation of zinc status may be beneficial in COVID'19. In vitro experiments demonstrate that Zn2+ possesses antiviral activity through inhibition of SARS'C oV RNA polymerase. This effect may underlie therapeutic efficiency of chloroquine known to act as zinc ionophore. Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin'converting enzyme 2 (ACE2), known to be the receptor for SARS'C oV'2. Improved antiviral immunity by zinc may also occur through up'regulation of interferon α production and increasing its antiviral activity. Zinc possesses anti'inflammatory activity by inhibiting NF'κB signaling and modulatio