An in silico simulation of flow-mediated dilation reveals that blood pressure and other factors may influence the response independent of...
Jin W., Chowienczyk P., Alastrue`j A. Kh.
American Journal of Physiology - Heart and Circulatory Physiology
Vol.318, Issue5, P. H1337-H1345
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1152/ajpheart.00703.2019
Аннотация:
Endothelial dysfunction is thought to underpin atherosclerotic cardiovascular disease. The most widely used in vivo test of endothelial function is flowmediated dilation (FMD). However, the results of FMD may be subject to some confounding factors that are not fully understood. We investigated potential biophysical confounding factors that could cause a disassociation between FMD and true endothelial cell shear stress response (the release of endothelium-dependent relaxing factors in response to wall shear stress). Arterial hemodynamics during FMD was simulated using a novel computational modeling approach. The model included an endothelial response function relating changes in wall shear stress to changes in local vascular stiffness in the arm arteries and accounted for vascular stiffening with increasing blood pressure. The hemodynamic effects of cuff inflation and deflation were modeled by prescribing intraluminal arterial pressure changes and peripheral vasodilation. Evolution of a
Ключевые слова:
Computer-based model; Endothelial function; Flow-induced dilation; Hemodynamics
adult; arterial stiffness; biological model; blood flow; blood pressure; human; male; physiology; vascular endothelium; vasodilatation; Adult; Blood Pressure; Endothelium, Vascular; Humans; Male; Models, Cardiovascular; Regional Blood Flow; Vascular Stiffness; Vasodilation
Язык текста: Английский
ISSN: 1522-1539
Jin W.
Chowienczyk P.
Alastrue`j A. Kh. Arimon Khordi 1978-
Йин W.
Чоwиенcзyк П.
Аластруэй А. Х. Аримон Хорди 1978-
An in silico simulation of flow-mediated dilation reveals that blood pressure and other factors may influence the response independent of endothelial function
An in silico simulation of flow-mediated dilation reveals that blood pressure and other factors may influence the response independent of...
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American Journal of Physiology - Heart and Circulatory Physiology
American Physiological Society
Vol.318, Issue5 P. H1337-H1345
2020
Статья
Computer-based model Endothelial function Flow-induced dilation Hemodynamics
adult arterial stiffness biological model blood flow blood pressure human male physiology vascular endothelium vasodilatation Adult Blood Pressure Endothelium, Vascular Humans Male Models, Cardiovascular Regional Blood Flow Vascular Stiffness Vasodilation
Endothelial dysfunction is thought to underpin atherosclerotic cardiovascular disease. The most widely used in vivo test of endothelial function is flowmediated dilation (FMD). However, the results of FMD may be subject to some confounding factors that are not fully understood. We investigated potential biophysical confounding factors that could cause a disassociation between FMD and true endothelial cell shear stress response (the release of endothelium-dependent relaxing factors in response to wall shear stress). Arterial hemodynamics during FMD was simulated using a novel computational modeling approach. The model included an endothelial response function relating changes in wall shear stress to changes in local vascular stiffness in the arm arteries and accounted for vascular stiffening with increasing blood pressure. The hemodynamic effects of cuff inflation and deflation were modeled by prescribing intraluminal arterial pressure changes and peripheral vasodilation. Evolution of a