Enzymatic degradation of the polymer capsules with a hydrophobic core in the presence of Langmuir lipid monolayer as a model of the cellular membrane
Mironov E. P., Borodina T. N., Yurina D. G., Trushina D. B., Bukreeva T. V.
Colloids and Surfaces B: Biointerfaces
Vol.184, Num.110464
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.colsurfb.2019.110464
Аннотация:
Submicrocapsules were prepared from diethylaminoethyl dextran (DEAE-D), xanthan gum (XG) and bovine serum albumin (BSA) on oil cores by ultrasonic treatment. These capsules were modified with poly-L-lysine (PLL) via electrostatic adsorption. The behavior of the capsules was investigated at an air–water interface after their introduction into an aqueous subphase. The interaction of the capsules with 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) monolayer formed on the water surface (model cellular membrane) was studied both upon their introduction under the condensed monolayer and with the use of a dilute colloidal solution of the capsules as a subphase. Biodegradation of the proteinaceous capsules with subsequent oil-core release was demonstrated by influence of pronase. The Langmuir lipid monolayer was found to be a good model for investigation of drug release from the capsules in the presence of the cellular membrane. © 2019 Elsevier B.V.
Ключевые слова:
Biodegradation; Hydrophobic materials; Langmuir monolayer; Model cellular membrane; Polymer capsules; Triggered release
Amino acids; Biodegradable polymers; Biodegradation; Controlled drug delivery; Hydrophobicity; Mammals; Phase interfaces; Sols; Targeted drug delivery; Xanthan gum; Cellular membranes; Hydrophobic Material; Langmuir monolayers; Polymer capsules; Triggered release; Monolayers; bovine serum albumin; diethylaminoethyldextran; dimyristoylphosphatidylcholine; polylysine; polymer; pronase; xanthan; lipid; polymer; water; adsorption; Article; biodegradation; colloid; dispersity; drug capsule; drug release; electrostatic adsorption; enzymatic degradation; lipid monolayer; priority journal; zeta potential; administration and dosage; animal; bovine; cell membrane; chemical phenomena; chemistry; delayed release formulation; lipid bilayer; metabolism; microcapsule; pharmacokinetics; static electricity; surface property; Adsorption; Animals; Capsules; Cattle; Cell Membrane; Delayed-Action Preparations; Drug Liberation; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers; Lipids; Polymers; Seru
Язык текста: Английский
ISSN: 1873-4367
Mironov E. P.
Borodina T. N. Tat`yana Nikolaevna 1982-
Yurina D. G.
Trushina D. B. Dar`ya Borisovna 1989-
Bukreeva T. V.
Миронов Е. П.
Бородина Т. Н. Татьяна Николаевна 1982-
Юрина Д. Г.
Трушина Д. Б. Дарья Борисовна 1989-
Букреева Т. В.
Enzymatic degradation of the polymer capsules with a hydrophobic core in the presence of Langmuir lipid monolayer as a model of the cellular membrane
Текст визуальный непосредственный
Colloids and Surfaces B: Biointerfaces
Elsevier Science Publisher B.V.
Vol.184 Num.110464
2019
Статья
Biodegradation Hydrophobic materials Langmuir monolayer Model cellular membrane Polymer capsules Triggered release
Amino acids Biodegradable polymers Biodegradation Controlled drug delivery Hydrophobicity Mammals Phase interfaces Sols Targeted drug delivery Xanthan gum Cellular membranes Hydrophobic Material Langmuir monolayers Polymer capsules Triggered release Monolayers bovine serum albumin diethylaminoethyldextran dimyristoylphosphatidylcholine polylysine polymer pronase xanthan lipid polymer water adsorption Article biodegradation colloid dispersity drug capsule drug release electrostatic adsorption enzymatic degradation lipid monolayer priority journal zeta potential administration and dosage animal bovine cell membrane chemical phenomena chemistry delayed release formulation lipid bilayer metabolism microcapsule pharmacokinetics static electricity surface property Adsorption Animals Capsules Cattle Cell Membrane Delayed-Action Preparations Drug Liberation Hydrophobic and Hydrophilic Interactions Lipid Bilayers Lipids Polymers Seru
Submicrocapsules were prepared from diethylaminoethyl dextran (DEAE-D), xanthan gum (XG) and bovine serum albumin (BSA) on oil cores by ultrasonic treatment. These capsules were modified with poly-L-lysine (PLL) via electrostatic adsorption. The behavior of the capsules was investigated at an air–water interface after their introduction into an aqueous subphase. The interaction of the capsules with 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) monolayer formed on the water surface (model cellular membrane) was studied both upon their introduction under the condensed monolayer and with the use of a dilute colloidal solution of the capsules as a subphase. Biodegradation of the proteinaceous capsules with subsequent oil-core release was demonstrated by influence of pronase. The Langmuir lipid monolayer was found to be a good model for investigation of drug release from the capsules in the presence of the cellular membrane. © 2019 Elsevier B.V.