Open Access Macedonian Journal of Medical Sciences
Vol.7, Issue13, P. 2079-2083
Аннотация:
BACKGROUND: The scientific substantiation for the selection of therapeutically significant dosage of phytocomplex in the dosage form for phonophoresis, control over the delivery of active substances into the body, and what affects this process require the study of the kinetics of phytocomplex flavonoids delivery during phonophoresis. AIM: The aim was to study the possibilities of controlling the process of transdermal delivery of phytocomplex active substances (flavonoids) during phonophoresis in vitro model experiments. METHODS: Working compositions with different concentrations of phytocomplex for phonophoresis were used. The content of flavonoids in the compositions was determined using the spectrophotometric method and was calculated equivalent to quercetin, the flavonoid prevailing in the phytocomplex. The study of the kinetics of flavonoids delivery from working compositions was carried out using Franz diffusion cells and Carbosyl-P membranes. The authors determined the main para
Ключевые слова:
Flavonoids; Phonophoresis; Plant extract; Transdermal delivery
flavonoid; phytochemical; quercetin; Article; drug formulation; flow kinetics; photometry; physical chemistry; process control; thermostability; transdermal drug delivery system; ultrasound; ultraviolet spectrophotometry; viscosity
Babaskina L. I. Lyudmila Ivanovna 1952-
Litvinova T. M. Tat`yana Mikhaylovna 1962-
Babaskin D. V. Dmitrij Vladimirovich 1979-
Kry'lova O. V. Ol`ga Valeryevna 1970-
Бабаскина Л. И. Людмила Ивановна 1952-
Литвинова Т. М. Татьяна Михайловна 1962-
Бабаскин Д. В. Дмитрий Владимирович 1979-
Крылова О. В. Ольга Валерьевна 1970-
Control of the transdermal delivery process of active substances of the phytocomplex during phonophoresis in model experiments
Текст визуальный непосредственный
Open Access Macedonian Journal of Medical Sciences
Open Access Macedonian Journal of Medical Sciences
Vol.7, Issue13 P. 2079-2083
2019
Статья
Flavonoids Phonophoresis Plant extract Transdermal delivery
flavonoid phytochemical quercetin Article drug formulation flow kinetics photometry physical chemistry process control thermostability transdermal drug delivery system ultrasound ultraviolet spectrophotometry viscosity
BACKGROUND: The scientific substantiation for the selection of therapeutically significant dosage of phytocomplex in the dosage form for phonophoresis, control over the delivery of active substances into the body, and what affects this process require the study of the kinetics of phytocomplex flavonoids delivery during phonophoresis. AIM: The aim was to study the possibilities of controlling the process of transdermal delivery of phytocomplex active substances (flavonoids) during phonophoresis in vitro model experiments. METHODS: Working compositions with different concentrations of phytocomplex for phonophoresis were used. The content of flavonoids in the compositions was determined using the spectrophotometric method and was calculated equivalent to quercetin, the flavonoid prevailing in the phytocomplex. The study of the kinetics of flavonoids delivery from working compositions was carried out using Franz diffusion cells and Carbosyl-P membranes. The authors determined the main para