Genomic variation among strains of Crithidia bombi and C. expoeki
Gerasimov E. S., Zemp N., Schmid-Hempel R., Schmid-Hempel P., Yurchenko V.
mSphere
Vol.4, Issue5, Num.e00482-19
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1128/mSphere.00482-19
Аннотация:
In this study, we sequenced and analyzed the genomes of 40 strains, in addition to the already-reported two type strains, of two Crithidia species infecting bumblebees in Alaska and Central Europe and demonstrated that different strains of Crithidia bombi and C. expoeki vary considerably in terms of single nucleotide polymorphisms and gene copy number. Based on the genomic structure, phylogenetic analyses, and the pattern of copy number variation, we confirmed the status of C. expoeki as a separate species. The Alaskan populations appear to be clearly separated from those of Central Europe. This pattern fits a scenario of rapid host-parasite coevolution, where the selective advantage of a given parasite strain is only temporary. This study provides helpful insights into possible scenarios of selection and diversification of trypanosomatid parasites. © 2019 Gerasimov et al.
Ключевые слова:
Crithidia; Genomics; Trypanosomatidae
Alaska; animal; bee; copy number variation; Crithidia; Europe; female; genetic variation; genetics; genome; genomics; host parasite interaction; parasitology; phylogeny; single nucleotide polymorphism; Alaska; Animals; Bees; Crithidia; DNA Copy Number Variations; Europe; Female; Genetic Variation; Genome, Protozoan; Genomics; Host-Parasite Interactions; Phylogeny; Polymorphism, Single Nucleotide
Язык текста: Английский
ISSN: 2379-5042
Gerasimov E. S. Evgenij Sergeevich 1985-
Zemp N.
Schmid-Hempel R.
Schmid-Hempel P.
Yurchenko V. Vyacheslav 1972-
Герасимов Е. С. Евгений Сергеевич 1985-
Земп Н.
Счмид-Хемпел Р.
Счмид-Хемпел П.
Юрченко В. Вячеслав 1972-
Genomic variation among strains of Crithidia bombi and C. expoeki
Текст визуальный непосредственный
mSphere
American Society for Microbiology
Vol.4, Issue5 Num.e00482-19
2019
Статья
Crithidia Genomics Trypanosomatidae
Alaska animal bee copy number variation Crithidia Europe female genetic variation genetics genome genomics host parasite interaction parasitology phylogeny single nucleotide polymorphism Alaska Animals Bees Crithidia DNA Copy Number Variations Europe Female Genetic Variation Genome, Protozoan Genomics Host-Parasite Interactions Phylogeny Polymorphism, Single Nucleotide
In this study, we sequenced and analyzed the genomes of 40 strains, in addition to the already-reported two type strains, of two Crithidia species infecting bumblebees in Alaska and Central Europe and demonstrated that different strains of Crithidia bombi and C. expoeki vary considerably in terms of single nucleotide polymorphisms and gene copy number. Based on the genomic structure, phylogenetic analyses, and the pattern of copy number variation, we confirmed the status of C. expoeki as a separate species. The Alaskan populations appear to be clearly separated from those of Central Europe. This pattern fits a scenario of rapid host-parasite coevolution, where the selective advantage of a given parasite strain is only temporary. This study provides helpful insights into possible scenarios of selection and diversification of trypanosomatid parasites. © 2019 Gerasimov et al.