Аннотация:
The aim of this work was to study the influence of components of dental status on the local immunity of the oral cavity; we compared the results of the study of patients with squamous cell carcinoma (SCC) of the oral mucosa and patients without neoplasm. The study involved 136 patients with squamous cell carcinoma of the oral mucosa and 57 patients without neoplasms. In the role of the constituent characteristics of dental status were examined: the use of removable and fixed dentures, dental caries, dental plaque, sharp edges of fullings. Matrix metalloproteinases (MMPs) 2, 8 and 9, as well as their tissue inhibitors 1 and 2 were assessed in oral fluid. The results suggest the influence of all factors on local immune status of the oral cavity as proved by the significant changes in MMPs level. The use of removable dentures resulted in the pronounced decrease of MMPs and should be considered in oral SSC screening and non-invasive diagnostics.Цель исследования - исследование влияния сост
Ключевые слова:
biomarkers; cancer; dental status; oral cavity; saliva
dental caries; health; human; mouth mucosa; mouth tumor; squamous cell carcinoma; Carcinoma, Squamous Cell; Dental Caries; Humans; Mouth Mucosa; Mouth Neoplasms; Oral Health
Кочурова Е. В. Екатерина Владимировна 1983-
Николенко В. Н. Владимир Николаевич 1956-
Муханов А. А. Александр Алексеевич 1993-
Деменчук П. А.
Kochurova E. V. Ekaterina Vladimirovna 1983-
Nikolenko V. N. Vladimir Nikolaevich 1956-
Mukhanov A. A. Aleksandr Alekseevich 1993-
Demenchuk P. A.
Dental status as a predictive factor in the development of squamous cell carcinoma of the oral mucosa [Stomatologicheskiĭ status kak prognosticheskiĭ faktor razvitiia ploskokletochnogo raka slizistoĭ obolochki polosti rta]
Dental status as a predictive factor in the development of squamous cell carcinoma of the oral mucosa [Stomatologicheskiĭ status kak...
Текст визуальный непосредственный
Стоматология
Издательство Медиа Сфера
Т. 98, Вып. 4 С. 34-37
2019
Статья
biomarkers cancer dental status oral cavity saliva
dental caries health human mouth mucosa mouth tumor squamous cell carcinoma Carcinoma, Squamous Cell Dental Caries Humans Mouth Mucosa Mouth Neoplasms Oral Health
The aim of this work was to study the influence of components of dental status on the local immunity of the oral cavity; we compared the results of the study of patients with squamous cell carcinoma (SCC) of the oral mucosa and patients without neoplasm. The study involved 136 patients with squamous cell carcinoma of the oral mucosa and 57 patients without neoplasms. In the role of the constituent characteristics of dental status were examined: the use of removable and fixed dentures, dental caries, dental plaque, sharp edges of fullings. Matrix metalloproteinases (MMPs) 2, 8 and 9, as well as their tissue inhibitors 1 and 2 were assessed in oral fluid. The results suggest the influence of all factors on local immune status of the oral cavity as proved by the significant changes in MMPs level. The use of removable dentures resulted in the pronounced decrease of MMPs and should be considered in oral SSC screening and non-invasive diagnostics.Цель исследования - исследование влияния сост