The effect of anticholinergic medications on cognitive function of patients 80 years and older with essential hypertension [Влияние лекарственных...
Остроумова О. Д., Куликова М. И., Сычев Д. А., Головина О. В., Черняева М. С.
Артериальная гипертензия
Т. 25, Вып. 3, С. 246-257
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.18705/1607-419X-2019-25-3-246-257
Аннотация:
Background. Cognitive impairment and dementia are the symptoms of brain damage in hypertension (HTN), which impair quality of life and autonomy, in particular, in elderly patients. However, the influence of various drugs on the cognitive functions remains unclear. objective. To assess the effect of anticholinergic drugs on cognitive functions in hypertensive patients aged 80 years and older. design and methods. We consistently included 74 patients (77 [%] women) aged 80 years and older (median age 86 [82-89] years) with essential HTN stage I-III, who were admitted to the Department of Internal Diseases at the multidisciplinary hospital. Inclusion criteria were the following: patients with essential HTN stage I-III of both sexes; 2) age at the time of inclusion in the study - 80 years and older; regular antihypertensive therapy. The main non-inclusion criteria were the following: 1) age less than 80 years; myocardial infarction during the previous 3 months; mental illness, dependence on d
Ключевые слова:
Adverse drug reactions; Anticholinergic Cognitive Burden Scale; Anticholinergic medications; Cognitive functions; Elderly age; Hypertension; Polypharmacy; сognitive impairment
cholinergic receptor blocking agent; aged; Alzheimer Disease Assessment Scale; Anticholinergic Cognitive Burden; antihypertensive therapy; Article; cognition; controlled study; depression; digit symbol substitution test; essential hypertension; female; Geriatric Depression Scale; human; major clinical study; male; mental disease assessment; Mini Mental State Examination; Montreal cognitive assessment; very elderly; Wechsler adult intelligence scale; word list recall
Язык текста: Русский
ISSN: 2411-8524
Остроумова О. Д. Ольга Дмитриевна 1968-
Куликова М. И.
Сычев Д. А. Дмитрий Алексеевич 1975-
Головина О. В.
Черняева М. С.
Ostroumova O. D. Ol`ga Dmitrievna 1968-
Kulikova M. I.
Sy'chev D. A. Dmitrij Alekseevich 1975-
Golovina O. V.
Chernyaeva M. S.
The effect of anticholinergic medications on cognitive function of patients 80 years and older with essential hypertension [Влияние лекарственных препаратов с антихолинергической активностью на когнитивные функции пациентов 80 лет и старше с эссенциальной артериальной гипертензией]
The effect of anticholinergic medications on cognitive function of patients 80 years and older with essential hypertension [Влияние лекарственных...
Текст визуальный непосредственный
Артериальная гипертензия
Общероссийская общественная организация "Антигипертензивная лига"
Т. 25, Вып. 3 С. 246-257
2019
Статья
Adverse drug reactions Anticholinergic Cognitive Burden Scale Anticholinergic medications Cognitive functions Elderly age Hypertension Polypharmacy сognitive impairment
cholinergic receptor blocking agent aged Alzheimer Disease Assessment Scale Anticholinergic Cognitive Burden antihypertensive therapy Article cognition controlled study depression digit symbol substitution test essential hypertension female Geriatric Depression Scale human major clinical study male mental disease assessment Mini Mental State Examination Montreal cognitive assessment very elderly Wechsler adult intelligence scale word list recall
Background. Cognitive impairment and dementia are the symptoms of brain damage in hypertension (HTN), which impair quality of life and autonomy, in particular, in elderly patients. However, the influence of various drugs on the cognitive functions remains unclear. objective. To assess the effect of anticholinergic drugs on cognitive functions in hypertensive patients aged 80 years and older. design and methods. We consistently included 74 patients (77 [%] women) aged 80 years and older (median age 86 [82-89] years) with essential HTN stage I-III, who were admitted to the Department of Internal Diseases at the multidisciplinary hospital. Inclusion criteria were the following: patients with essential HTN stage I-III of both sexes; 2) age at the time of inclusion in the study - 80 years and older; regular antihypertensive therapy. The main non-inclusion criteria were the following: 1) age less than 80 years; myocardial infarction during the previous 3 months; mental illness, dependence on d