Ex vivo properties of plasma clot formation and lysis in patients with cancer at risk for venous thromboembolism, arterial thrombosis, and death
Posch F., Hofer S., Thaler J., Hell L., Königsbrügge O., Grilz E., Mauracher L. -., Gebhart J., Marosi C., Jilma B., Pabinger I., d m. n. A. D.
Translational Research
Vol.215, P. 41-56
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1016/j.trsl.2019.08.009
Аннотация:
A prothrombotic state is frequently observed in patients with cancer and contributes to the risks of venous thromboembolism (VTE), arterial thromboembolism (ATE), tumor progression, and death. Altered ex vivo properties of plasma clot formation and lysis have been observed in patients with cancer. The aim of this prospective study was to comprehensively characterize the relationship between plasma clot properties, inflammation, hypercoagulability, thrombotic complications, and mortality in patients with cancer using a tissue-factor-based turbidimetric assay of clot formation and lysis. Turbidity parameters were determined in 815 patients with newly-diagnosed or recurrent cancer and 97 healthy controls. Patients were followed-up for 2 years and rates of VTE (n = 72 events), ATE (n = 21 events), and death (n = 304 events) were assessed. Compared to controls, cancer patients’ turbidity profiles showed an increased clot formation potential and higher resistance toward fibrinolysis. Elevate
Ключевые слова:
blood clotting factor 8; C reactive protein; D dimer; fibrin; fibrinogen; PADGEM protein; thrombin; biological marker; adult; aged; arterial thromboembolism; Article; blood clotting; cancer recurrence; cohort analysis; comparative study; controlled study; death; euglobulin lysis test; ex vivo study; female; fibrin formation; fibrinolysis; follow up; hemostasis; human; hypercoagulability; inflammation; lysis; major clinical study; male; malignant neoplasm; mortality; priority journal; prospective study; risk; turbidity; venous thromboembolism; artery; blood; case control study; fibrinolysis; middle aged; mortality; multivariate analysis; neoplasm; pathology; prognosis; risk factor; statistical model; thrombosis; treatment outcome; venous thromboembolism; Aged; Arteries; Biomarkers; Blood Coagulation; Case-Control Studies; Cohort Studies; Death; Female; Fibrinolysis; Follow-Up Studies; Hemostasis; Humans; Inflammation; Linear Models; Male; Middle Aged; Multivariate Analysis; Neoplasms; P
Язык текста: Английский
ISSN: 1878-1810
Posch F.
Hofer S.
Thaler J.
Hell L.
Königsbrügge O.
Grilz E.
Mauracher L. -. L.-M.
Gebhart J.
Marosi C.
Jilma B.
Pabinger I.
m. n. A. D. m n Ay Dzhikhan 1980-
Посч Ф.
Хофер С.
Тхалер Й.
Хелл Л.
Кöнигсбрüгге О.
Грилз Е.
Маурачер Л. -. Л.-М.
Гебхарт Й.
Мароси C.
Йилма Б.
Пабингер И.
м. н. А. Д. м н Ай Джихан 1980-
Ex vivo properties of plasma clot formation and lysis in patients with cancer at risk for venous thromboembolism, arterial thrombosis, and death
Текст визуальный непосредственный
Translational Research
Mosby
Vol.215 P. 41-56
2020
Статья
blood clotting factor 8 C reactive protein D dimer fibrin fibrinogen PADGEM protein thrombin biological marker adult aged arterial thromboembolism Article blood clotting cancer recurrence cohort analysis comparative study controlled study death euglobulin lysis test ex vivo study female fibrin formation fibrinolysis follow up hemostasis human hypercoagulability inflammation lysis major clinical study male malignant neoplasm mortality priority journal prospective study risk turbidity venous thromboembolism artery blood case control study fibrinolysis middle aged mortality multivariate analysis neoplasm pathology prognosis risk factor statistical model thrombosis treatment outcome venous thromboembolism Aged Arteries Biomarkers Blood Coagulation Case-Control Studies Cohort Studies Death Female Fibrinolysis Follow-Up Studies Hemostasis Humans Inflammation Linear Models Male Middle Aged Multivariate Analysis Neoplasms
A prothrombotic state is frequently observed in patients with cancer and contributes to the risks of venous thromboembolism (VTE), arterial thromboembolism (ATE), tumor progression, and death. Altered ex vivo properties of plasma clot formation and lysis have been observed in patients with cancer. The aim of this prospective study was to comprehensively characterize the relationship between plasma clot properties, inflammation, hypercoagulability, thrombotic complications, and mortality in patients with cancer using a tissue-factor-based turbidimetric assay of clot formation and lysis. Turbidity parameters were determined in 815 patients with newly-diagnosed or recurrent cancer and 97 healthy controls. Patients were followed-up for 2 years and rates of VTE (n = 72 events), ATE (n = 21 events), and death (n = 304 events) were assessed. Compared to controls, cancer patients’ turbidity profiles showed an increased clot formation potential and higher resistance toward fibrinolysis. Elevate