Eosinopenia, in Chronic Spontaneous Urticaria, Is Associated with High Disease Activity, Autoimmunity, and Poor Response to Treatment
Kolkhir P. V., Church M. K., Altrichter S., Skov P. S., Hawro T., Frischbutter S., Metz M., Maurer M.
Journal of Allergy and Clinical Immunology: In Practice
Vol.8, Issue1, P. 318-325.e5
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1016/j.jaip.2019.08.025
Аннотация:
Background: Chronic spontaneous urticaria (CSU) is characterized by the degranulation of skin mast cells and the influx of basophils and eosinophils to affected skin sites. Blood basopenia has been linked to severe antihistamine-resistant CSU and type IIb autoimmunity, whereas the role of eosinophils in CSU is largely unknown. Objective: To analyze data from 1613 patients with CSU from 2 centers to study the prevalence, role, and relevance of eosinopenia in CSU. Methods: Peripheral blood eosinophil and basophil counts were measured by automated hematology analyzers. Patient files were screened for clinical characteristics, results of laboratory tests, the autologous serum skin test, the serum-induced basophil histamine release assay, and response to second-generation H1-antihistamines and omalizumab. Results: Ten percent of patients with CSU had eosinopenia. Eosinopenia was associated with the female sex, high disease activity, autologous serum skin test and basophil histamine release
Ключевые слова:
Antihistamines; ASST; Basophils; BHRA; Biomarker; Chronic spontaneous urticaria; Disease activity; Eosinopenia; Eosinophils; Omalizumab
C reactive protein; corticosteroid; histamine H1 receptor antagonist; immunoglobulin E; immunoglobulin G antibody; omalizumab; thyroid peroxidase antibody; adolescent; adult; aged; Article; autoimmunity; basophil; chronic urticaria; controlled study; disease activity; drug efficacy; drug megadose; drug response; eosinopenia; eosinophil count; female; histamine release; human; major clinical study; male; prediction; prevalence; sex; skin test
Язык текста: Английский
ISSN: 2213-2201
Kolkhir P. V. Pavel Vladimirovich 1982-
Church M. K.
Altrichter S.
Skov P. S.
Hawro T.
Frischbutter S.
Metz M.
Maurer M.
Колхир П. В. Павел Владимирович 1982-
Чурч М. К.
Алтричтер С.
Сков П. С.
Хаwро Т.
Фрисчбуттер С.
Метз М.
Маурер М.
Eosinopenia, in Chronic Spontaneous Urticaria, Is Associated with High Disease Activity, Autoimmunity, and Poor Response to Treatment
Текст визуальный непосредственный
Journal of Allergy and Clinical Immunology: In Practice
Vol.8, Issue1 P. 318-325.e5
2020
Статья
Antihistamines ASST Basophils BHRA Biomarker Chronic spontaneous urticaria Disease activity Eosinopenia Eosinophils Omalizumab
C reactive protein corticosteroid histamine H1 receptor antagonist immunoglobulin E immunoglobulin G antibody omalizumab thyroid peroxidase antibody adolescent adult aged Article autoimmunity basophil chronic urticaria controlled study disease activity drug efficacy drug megadose drug response eosinopenia eosinophil count female histamine release human major clinical study male prediction prevalence sex skin test
Background: Chronic spontaneous urticaria (CSU) is characterized by the degranulation of skin mast cells and the influx of basophils and eosinophils to affected skin sites. Blood basopenia has been linked to severe antihistamine-resistant CSU and type IIb autoimmunity, whereas the role of eosinophils in CSU is largely unknown. Objective: To analyze data from 1613 patients with CSU from 2 centers to study the prevalence, role, and relevance of eosinopenia in CSU. Methods: Peripheral blood eosinophil and basophil counts were measured by automated hematology analyzers. Patient files were screened for clinical characteristics, results of laboratory tests, the autologous serum skin test, the serum-induced basophil histamine release assay, and response to second-generation H1-antihistamines and omalizumab. Results: Ten percent of patients with CSU had eosinopenia. Eosinopenia was associated with the female sex, high disease activity, autologous serum skin test and basophil histamine release