Therapeutic effect of human umbilical cord-derived multipotent mesenchymal stromal cells in a patient with Crigler-Najjar syndrome type i
Сухих Г. Т., Дегтярева А. В., Силачев Д. Н., Горунов К. В., Дубровина И. В., Ушакова Л. В., Дегтярев Д. Н.
Российский вестник перинатологии и педиатрии
Т. 64, Вып. 4, С. 26-34
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.21508/1027-4065-2019-64-4-26-34
Аннотация:
The article presents the results of intravenous transplantation of allogeneic multipotent mesenchymal stromal cells, derived from a human umbilical cord, to a child with Crigler-Najjar syndrome type I during the first 2 years of life. The therapy is aimed at reduction of the duration of phototherapy while maintaining a safe level of serum bilirubin. In this study, a five-day-old child with the bilirubin level of 340 μmol/l was treated with phototherapy for 16-18 hours daily in the neonatal period. Then, phototherapy was reduced to 14-16 hours. The level of bilirubin varied from 329 to 407 μ mol/l. At the age of 2 months, it was decided to use multipotent mesenchymal stromal cells with a significant decrease in the duration of phototherapy up to 2 hours a day. During the observation period (2 years at the time of writing this article) the child received 6 injections of multipotent mesenchymal stromal cells. A positive effect developed within 4-7 days after administration and persisted f
Ключевые слова:
Crigler-Naiar syndrome; Hyperbilirubinemia; Multipotent mesenchymal stromal cells; Newborns; Phototherapy
Язык текста: Русский
ISSN: 2500-2228
Сухих Г. Т. Геннадий Тихонович 1947-
Дегтярева А. В. Анна Владимировна 1971-
Силачев Д. Н.
Горунов К. В.
Дубровина И. В.
Ушакова Л. В.
Дегтярев Д. Н. Дмитрий Николаевич 1960-
Sukhikh G. T. Gennadij Tikhonovich 1947-
Degtyareva A. V. Anna Vladimirovna 1971-
Silachev D. N.
Gorunov K. V.
Dubrovina I. V.
Ushakova L. V.
Degtyarev D. N. Dmitrij Nikolaevich 1960-
Therapeutic effect of human umbilical cord-derived multipotent mesenchymal stromal cells in a patient with Crigler-Najjar syndrome type i
Текст визуальный непосредственный
Российский вестник перинатологии и педиатрии
Национальная педиатрическая академия науки и инноваций
Т. 64, Вып. 4 С. 26-34
2019
Статья
Crigler-Naiar syndrome Hyperbilirubinemia Multipotent mesenchymal stromal cells Newborns Phototherapy
The article presents the results of intravenous transplantation of allogeneic multipotent mesenchymal stromal cells, derived from a human umbilical cord, to a child with Crigler-Najjar syndrome type I during the first 2 years of life. The therapy is aimed at reduction of the duration of phototherapy while maintaining a safe level of serum bilirubin. In this study, a five-day-old child with the bilirubin level of 340 μmol/l was treated with phototherapy for 16-18 hours daily in the neonatal period. Then, phototherapy was reduced to 14-16 hours. The level of bilirubin varied from 329 to 407 μ mol/l. At the age of 2 months, it was decided to use multipotent mesenchymal stromal cells with a significant decrease in the duration of phototherapy up to 2 hours a day. During the observation period (2 years at the time of writing this article) the child received 6 injections of multipotent mesenchymal stromal cells. A positive effect developed within 4-7 days after administration and persisted f