Аннотация:
Background: Organic acids (malic, citric, tartaric, oxalic, acetic, formic, isovaleric, ascorbic acids) make up a large group of biologically active substances and play an important role in plant and human metabolism. They are found in large quantities in the fruits of Rosaceae family medicinal plants that included in State Pharmacopoeia of the Russian Federation. Standardization of crude herbal drugs containing organic acids by modern physicochemical methods is a high-priority task. Materials and methods: The determination of total organic acids amount was carried out in aqueous extracts from different fruits of Rosaceae family plants by galvanostatic coulometry and potentiometry methods. Galvanostatic coulometry was performed with the help of the "Expert-006" coulometer with a current of 5 mA (integrated pH meter). Iodine as an electrogenerated titrant was used for ascorbic acid determination; electro generation of hydroxide ions was carried out for determination of total organic aci
Ключевые слова:
Coulometry; Crude herbal drugs; High performance liquid chromatography; Organic acids; Potentiometry; Redox titration; Titrimetric Methods
acetonitrile; ascorbic acid; carboxylic acid; herbaceous agent; hydrochloric acid; iodine; phosphoric acid; silver chloride; sodium hydroxide; accuracy; Article; chemical reaction; column chromatography; coulometry; elution; limit of detection; limit of quantitation; pH; physical chemistry; potentiometric titration; potentiometry; qualitative analysis; quality control; quantitative analysis; reversed phase high performance liquid chromatography; Russian Federation; titrimetry
Sergunova E. V. Ekaterina Vyacheslavovna 1975-
Sorokina A. A. Alla Anatolyevna 1950-
Bokov D. O. Dmitrij Olegovich 1991-
Marakhova A. I. Anna Igorevna 1985-
Сергунова Е. В. Екатерина Вячеславовна 1975-
Сорокина А. А. Алла Анатольевна 1950-
Боков Д. О. Дмитрий Олегович 1991-
Марахова А. И. Анна Игоревна 1985-
Qualitative and quantitative determination of organic acids in crude herbal drugs and medicinal herbal preparations for quality control in Russian Federation by modern physicochemical methods
Qualitative and quantitative determination of organic acids in crude herbal drugs and medicinal herbal preparations for quality control in Russian...
Текст визуальный непосредственный
Pharmacognosy Journal
Pharmacognosy Network Worldwide
Vol.11, Issue5 P. 1132-1137
2019
Статья
Coulometry Crude herbal drugs High performance liquid chromatography Organic acids Potentiometry Redox titration Titrimetric Methods
acetonitrile ascorbic acid carboxylic acid herbaceous agent hydrochloric acid iodine phosphoric acid silver chloride sodium hydroxide accuracy Article chemical reaction column chromatography coulometry elution limit of detection limit of quantitation pH physical chemistry potentiometric titration potentiometry qualitative analysis quality control quantitative analysis reversed phase high performance liquid chromatography Russian Federation titrimetry
Background: Organic acids (malic, citric, tartaric, oxalic, acetic, formic, isovaleric, ascorbic acids) make up a large group of biologically active substances and play an important role in plant and human metabolism. They are found in large quantities in the fruits of Rosaceae family medicinal plants that included in State Pharmacopoeia of the Russian Federation. Standardization of crude herbal drugs containing organic acids by modern physicochemical methods is a high-priority task. Materials and methods: The determination of total organic acids amount was carried out in aqueous extracts from different fruits of Rosaceae family plants by galvanostatic coulometry and potentiometry methods. Galvanostatic coulometry was performed with the help of the "Expert-006" coulometer with a current of 5 mA (integrated pH meter). Iodine as an electrogenerated titrant was used for ascorbic acid determination; electro generation of hydroxide ions was carried out for determination of total organic aci