Adipocytokines in metabolically healthy obesity
Shulkina S. G., Smirnova E. N., Yudin M. I., Osadchuk M. A., Trushin M. V.
Italian Journal of Medicine
Vol.13, Issue3, P. 169-175
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.4081/itjm.2019.1075
Аннотация:
The aim of the investigation was to study the relationship among adipokines, markers of subclinical inflammation and endothelial dysfunction in patients with metabolic healthy obesity (MHO). The study included 50 persons aged 25-50 years with obesity in the absence of metabolic disorders (International Diabetes Federation criteria, 2005, marked as MHO), the control group consisted of 50 healthy respondents without obesity. We studied clinical and biochemical parameters, insulin resistance index (HOMA-IR), levels of leptin, soluble leptin receptors (sLR), resistin, adiponectin, C-reactive protein (CRP-hs), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), von Willebrand factor, free leptin index was calculated in a formula (FLI = leptin . 100/sLR). In MHO patients, independently of HOMA-IR index, there was an increase in leptin, FLI, resistin, VEGF, and IL-6 parameters. The concentration of CRP-hs and TNF-α in MHO
Ключевые слова:
Adipocytokines; Endothelium; Metabolically healthy obesity
adipocytokine; adiponectin; C reactive protein; endothelin 1; high density lipoprotein; leptin; leptin receptor; resistin; tumor necrosis factor; vasculotropin; von Willebrand factor; adult; Article; clinical article; controlled study; diabetes mellitus; diastolic blood pressure; endothelial dysfunction; female; homeostasis model assessment; human; inflammation; insulin resistance; insulin sensitivity; male; metabolically healthy obese; obesity; polyacrylamide gel electrophoresis; systolic blood pressure
Язык текста: Английский
ISSN: 1877-9344
Shulkina S. G.
Smirnova E. N.
Yudin M. I.
Osadchuk M. A. Mikhail Alekseevich 1951-
Trushin M. V.
Шулкина С. Г.
Смирнова Е. Н.
Юдин М. И.
Осадчук М. А. Михаил Алексеевич 1951-
Трушин М. В.
Adipocytokines in metabolically healthy obesity
Текст визуальный непосредственный
Italian Journal of Medicine
Vol.13, Issue3 P. 169-175
2019
Статья
Adipocytokines Endothelium Metabolically healthy obesity
adipocytokine adiponectin C reactive protein endothelin 1 high density lipoprotein leptin leptin receptor resistin tumor necrosis factor vasculotropin von Willebrand factor adult Article clinical article controlled study diabetes mellitus diastolic blood pressure endothelial dysfunction female homeostasis model assessment human inflammation insulin resistance insulin sensitivity male metabolically healthy obese obesity polyacrylamide gel electrophoresis systolic blood pressure
The aim of the investigation was to study the relationship among adipokines, markers of subclinical inflammation and endothelial dysfunction in patients with metabolic healthy obesity (MHO). The study included 50 persons aged 25-50 years with obesity in the absence of metabolic disorders (International Diabetes Federation criteria, 2005, marked as MHO), the control group consisted of 50 healthy respondents without obesity. We studied clinical and biochemical parameters, insulin resistance index (HOMA-IR), levels of leptin, soluble leptin receptors (sLR), resistin, adiponectin, C-reactive protein (CRP-hs), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), von Willebrand factor, free leptin index was calculated in a formula (FLI = leptin . 100/sLR). In MHO patients, independently of HOMA-IR index, there was an increase in leptin, FLI, resistin, VEGF, and IL-6 parameters. The concentration of CRP-hs and TNF-α in MHO