Exhaled breath mass spectrometry in heart failure diagnostics
Malinovskaya L., Bykova A., Chomakhidze P. Sh., Kopy'lov F. Yu., Sy'rkin A. L., Patrikeev L., Vasilev V., Belyakov V., Golovin A., Pershenkov V., Malkin E., Gromov E., Ivanov I., Matusko M., Shaltaeva Y., Betelin V.
International Journal of Nanotechnology
Vol.16, Issue1-3, P. 147-161
Опубликовано: 2019
Тип ресурса: Материалы конференции (Статья)
DOI:10.1504/IJNT.2019.102401
Аннотация:
Heart failure (HF) affects almost all organs and systems, including general and local pulmonary metabolism, thus effecting on volatile organic compounds concentration in expired air. The aim of the present study is to evaluate the value of expired air analysis (proton mass spectrometry, PTR-MS) for the diagnosis of HF. The study population included 19 patients with stable chronic New York Heart Association (NYHA) functional classification class 2-3 and 16 sex and age matched controls without signs and symptoms of HF. Expired air analysis could provide facilities of early diagnosis and monitoring in HF patients. Most patients had ischemic aetiology of HF, and 31[%] of them had NYHA class 2 and 69[%] NYHA class 3 symptoms. Fasted expired air collected by special Tedlar bags was analysed by Compact PTR-MS. The composition of expired air was analysed by deviation of the content of certain substances against their concentration in neutral air. Analysis of samples from patients reveals 24 substa
Ключевые слова:
Heart failure; New York Heart Association (NYHA) Functional Classification; Proton mass spectrometry; Student's t-test for independent; Volatile organic compounds
Acetone; Cardiology; Failure (mechanical); Heart; Mass spectrometry; Volatile organic compounds; Age-matched controls; Early diagnosis; Exhaled breaths; Expired air; Functional classification; Heart failure; Student's t tests; Tedlar bags; Diagnosis
Язык текста: Английский
ISSN: 1741-8151
Malinovskaya L.
Bykova A.
Chomakhidze P. Sh. Petr Shalvovich 1975-
Kopy'lov F. Yu. Filipp Yuryevich 1976-
Sy'rkin A. L. Abram L`vovich 1930-
Patrikeev L.
Vasilev V.
Belyakov V.
Golovin A.
Pershenkov V.
Malkin E.
Gromov E.
Ivanov I.
Matusko M.
Shaltaeva Y.
Betelin V.
Малиновскайа Л.
Бyкова А.
Чомахидзе П. Ш. Петр Шалвович 1975-
Копылов Ф. Ю. Филипп Юрьевич 1976-
Сыркин А. Л. Абрам Львович 1930-
Патрикеев Л.
Василев В.
Беляков В.
Головин А.
Першенков В.
Малкин Е.
Громов Е.
Иванов И.
Матюско М.
Шалтаева Y.
Бетелин В.
Exhaled breath mass spectrometry in heart failure diagnostics
Текст визуальный непосредственный
International Journal of Nanotechnology
Inderscience Publishers
Vol.16, Issue1-3 P. 147-161
2019
Материалы конференции (Статья)
Heart failure New York Heart Association (NYHA) Functional Classification Proton mass spectrometry Student's t-test for independent Volatile organic compounds
Acetone Cardiology Failure (mechanical) Heart Mass spectrometry Volatile organic compounds Age-matched controls Early diagnosis Exhaled breaths Expired air Functional classification Heart failure Student's t tests Tedlar bags Diagnosis
Heart failure (HF) affects almost all organs and systems, including general and local pulmonary metabolism, thus effecting on volatile organic compounds concentration in expired air. The aim of the present study is to evaluate the value of expired air analysis (proton mass spectrometry, PTR-MS) for the diagnosis of HF. The study population included 19 patients with stable chronic New York Heart Association (NYHA) functional classification class 2-3 and 16 sex and age matched controls without signs and symptoms of HF. Expired air analysis could provide facilities of early diagnosis and monitoring in HF patients. Most patients had ischemic aetiology of HF, and 31[%] of them had NYHA class 2 and 69[%] NYHA class 3 symptoms. Fasted expired air collected by special Tedlar bags was analysed by Compact PTR-MS. The composition of expired air was analysed by deviation of the content of certain substances against their concentration in neutral air. Analysis of samples from patients reveals 24 substa