Associations of snps of the adipoq gene with serum adiponectin levels, unstable angina, and coronary artery disease
Smetnev S., Klimushina M., Kutsenko V., Kiseleva A., Gumanova N., Kots A., Skirko O., Ershova A., Yarovaya E., Metelskaya V., Meshkov A., Drapkina O. M.
Biomolecules
Vol.9, Issue10, Num.537
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
Adiponectin is encoded by the ADIPOQ gene and participates in the pathogenesis of cardiovascular and metabolic diseases. The goal of the study was to assess associations of rs17300539, rs266729, rs182052, rs2241766, and rs17366743 single nucleotide polymorphisms (SNPs) of the ADIPOQ gene with concentrations of serum adiponectin and with coronary atherosclerosis and type 2 diabetes mellitus in 447 patients (316 men and 131 women) subjected to coronary angiography. SNPs of the ADIPOQ gene of the study participants were genotyped using real-time PCR. Multivariate linear regression adjusted for covariates revealed significant association between rs182052 SNP and serum adiponectin concentration (β= –0.11; 95[%] confidence interval (95[%]CI): – 0.19, –0.03; p = 0.016). Regression analysis revealed an increase in prevalence of unstable angina (OR (odds ratio) = 2.55; 95[%]CI 1.4–4.82; p = 0.018) and coronary artery disease (OR = 1.55; 95[%]CI 1.15– 2.09; p = 0.021) per copy of the rs182052 A allele.
Ключевые слова:
Adiponectin; ADIPOQ; Coronary artery disease; Genetic markers; Single-nucleotide polymorphisms
adiponectin; adult; Article; cohort analysis; coronary angiography; coronary artery atherosclerosis; coronary artery disease; female; gene frequency; haplotype; human; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; prevalence; real time polymerase chain reaction; Russian (people); single nucleotide polymorphism; unstable angina pectoris
Язык текста: Английский
ISSN: 2218-273X
Smetnev S.
Klimushina M.
Kutsenko V.
Kiseleva A.
Gumanova N.
Kots A. Aleksandr 1967-
Skirko O.
Ershova A.
Yarovaya E.
Metelskaya V.
Meshkov A.
Drapkina O. M. Oksana Mikhaylovna 1969-
Сметнев С.
Климушина М.
Куценко В.
Киселева А.
Гуманова Н.
Коц А. Александр 1967-
Скирко О.
Ершова А.
Яровайа Е.
Метелскайа В.
Мешков А.
Драпкина О. М. Оксана Михайловна 1969-
Associations of snps of the adipoq gene with serum adiponectin levels, unstable angina, and coronary artery disease
Текст визуальный непосредственный
Biomolecules
Vol.9, Issue10 Num.537
2019
Статья
Adiponectin ADIPOQ Coronary artery disease Genetic markers Single-nucleotide polymorphisms
adiponectin adult Article cohort analysis coronary angiography coronary artery atherosclerosis coronary artery disease female gene frequency haplotype human major clinical study male middle aged non insulin dependent diabetes mellitus prevalence real time polymerase chain reaction Russian (people) single nucleotide polymorphism unstable angina pectoris
Adiponectin is encoded by the ADIPOQ gene and participates in the pathogenesis of cardiovascular and metabolic diseases. The goal of the study was to assess associations of rs17300539, rs266729, rs182052, rs2241766, and rs17366743 single nucleotide polymorphisms (SNPs) of the ADIPOQ gene with concentrations of serum adiponectin and with coronary atherosclerosis and type 2 diabetes mellitus in 447 patients (316 men and 131 women) subjected to coronary angiography. SNPs of the ADIPOQ gene of the study participants were genotyped using real-time PCR. Multivariate linear regression adjusted for covariates revealed significant association between rs182052 SNP and serum adiponectin concentration (β= –0.11; 95[%] confidence interval (95[%]CI): – 0.19, –0.03; p = 0.016). Regression analysis revealed an increase in prevalence of unstable angina (OR (odds ratio) = 2.55; 95[%]CI 1.4–4.82; p = 0.018) and coronary artery disease (OR = 1.55; 95[%]CI 1.15– 2.09; p = 0.021) per copy of the rs182052 A allele.