Mitochondrial calcium uniporter structure and function in different types of muscle tissues in health and disease
Tarasova N. V., Vishnyakova P. A., Logashina Yu. A., Elchaninov A. V.
International Journal of Molecular Sciences
Vol.20, Issue19, Num.4823
Опубликовано: 2019
Тип ресурса: Обзор
Аннотация:
Calcium ions (Ca2+) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca2+ currents through the inner mitochondrial membrane. Extensive investigations of mtCU involvement into normal and pathological molecular pathways started from the moment of discovery of its molecular components. A crucial role of mtCU in the control of these pathways is now recognized in both health and disease. In particular, impairments of mtCU function have been demonstrated for cardiovascular and skeletal muscle-associated pathologies. This review summarizes the current state of knowledge on mtCU structure, regulation, and function in different types of muscle tissues in health and disease. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Ключевые слова:
Calcium; Calcium homeostasis; Calcium signaling; Mitochondrial calcium uniporter; Myocardium; Regulatory pathways; Skeletal muscle; Smooth muscle
essential mitochondrial calcium uniporter regulator; mitochondrial calcium uniporter; mitochondrial calcium uniporter complex; mitochondrial calcium uniporter pore forming subunit; mitochondrial calcium uptake 1; mitochondrial calcium uptake 2; mitochondrial protein; unclassified drug; calcium; calcium channel; mitochondrial calcium uniporter; aging; arrhythmogenesis; cardiac muscle; electrophysiology; heart failure; heart function; heart ventricle hypertrophy; human; intracellular signaling; muscle disease; muscle injury; muscle tissue; myocardial ischemia reperfusion injury; nonhuman; protein function; protein structure; regulatory mechanism; Review; skeletal muscle; smooth muscle; animal; calcium signaling; chemistry; disease predisposition; metabolism; muscle; signal transduction; structure activity relation; Animals; Calcium; Calcium Channels; Calcium Signaling; Disease Susceptibility; Electrophysiological Phenomena; Humans; Muscle, Skeletal; Muscle, Smooth; Muscles; Myocardium; S
Язык текста: Английский
ISSN: 1661-6596
Tarasova N. V. Nadezhda Valeryevna 1982-
Vishnyakova P. A.
Logashina Yu. A. Yuliya Aleksandrovna 1988-
Elchaninov A. V.
Тарасова Н. В. Надежда Валерьевна 1982-
Вишнякова П. А.
Логашина Ю. А. Юлия Александровна 1988-
Елчанинов А. В.
Mitochondrial calcium uniporter structure and function in different types of muscle tissues in health and disease
Текст визуальный непосредственный
International Journal of Molecular Sciences
Vol.20, Issue19 Num.4823
2019
Обзор
Calcium Calcium homeostasis Calcium signaling Mitochondrial calcium uniporter Myocardium Regulatory pathways Skeletal muscle Smooth muscle
essential mitochondrial calcium uniporter regulator mitochondrial calcium uniporter mitochondrial calcium uniporter complex mitochondrial calcium uniporter pore forming subunit mitochondrial calcium uptake 1 mitochondrial calcium uptake 2 mitochondrial protein unclassified drug calcium calcium channel mitochondrial calcium uniporter aging arrhythmogenesis cardiac muscle electrophysiology heart failure heart function heart ventricle hypertrophy human intracellular signaling muscle disease muscle injury muscle tissue myocardial ischemia reperfusion injury nonhuman protein function protein structure regulatory mechanism Review skeletal muscle smooth muscle animal calcium signaling chemistry disease predisposition metabolism muscle signal transduction structure activity relation Animals Calcium Calcium Channels Calcium Signaling Disease Susceptibility Electrophysiological Phenomena Humans Muscle, Skeletal Muscle, Smooth Muscles Myocardium
Calcium ions (Ca2+) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca2+ currents through the inner mitochondrial membrane. Extensive investigations of mtCU involvement into normal and pathological molecular pathways started from the moment of discovery of its molecular components. A crucial role of mtCU in the control of these pathways is now recognized in both health and disease. In particular, impairments of mtCU function have been demonstrated for cardiovascular and skeletal muscle-associated pathologies. This review summarizes the current state of knowledge on mtCU structure, regulation, and function in different types of muscle tissues in health and disease. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.