Кардиоваскулярная терапия и профилактика
Т. 18, Вып. 4, С. 109-114
Аннотация:
Atrial fibrillation (AF) is one of the most common heart rhythm disorders. AF worsens the quality of life of patients and increases the risk of fatal cardiovascular complications. Obesity is a worldwide epidemic which prevalence has doubled in the past 30 years. The role of obesity as one of the predisposing factors for AF is currently being discussed. The modern literature describes several mechanisms of the influence of overweight on the development of arrhythmias: activation of the sympatho-adrenal nervous system, increased activity of the reninangiotensin- aldosterone system, development of arterial hypertension, insulin resistance, and lipid metabolism. Despite the large number of studies in this area, the pathogenesis of the development and progression of AF in obesity is not fully understood. The molecular mechanisms of AF development in obese patients include the occurrence of systemic inflammation. The most significant inflammatory activity is observed in the epicardial adipos
Ключевые слова:
Adipokines; Atrial fibrillation; Epicardial adipose tissue; Inflammation; Obesity
cytokine; adipocyte; antiinflammatory activity; arrhythmogenesis; Article; atrial fibrillation; cardiovascular disease; disease course; epicardial fat; heart arrhythmia; human; hypertension; insulin resistance; lipid metabolism; molecular mechanics; obesity; pathogenesis; personalized medicine; prevalence; quality of life; renin angiotensin aldosterone system
Подзолков В. �. Валерий ��ванович 1948-
Тарзиманова А. И. Аида Ильгизовна 1978-
Гатаулин Р. Г. Радик Габдуллович 1993-
Оганесян К. А. Каринэ Арсеновна 1970-
Лобова Н. В. Наталья Вячеславовна 1977-
Podzolkov V. �. Valerij ��vanovich 1948-
Tarzimanova A. I. Aida Il`gizovna 1978-
Gataulin R. G. Radik Gabdullovich 1993-
Oganesyan K. A. Karine` Arsenovna 1970-
Lobova N. V. Natal`ya Vyacheslavovna 1977-
The role of obesity in the development of atrial fibrillation: Current problem status
Текст визуальный непосредственный
Кардиоваскулярная терапия и профилактика
ООО "Силицея-Полиграф"
Т. 18, Вып. 4 С. 109-114
2019
Статья
Adipokines Atrial fibrillation Epicardial adipose tissue Inflammation Obesity
cytokine adipocyte antiinflammatory activity arrhythmogenesis Article atrial fibrillation cardiovascular disease disease course epicardial fat heart arrhythmia human hypertension insulin resistance lipid metabolism molecular mechanics obesity pathogenesis personalized medicine prevalence quality of life renin angiotensin aldosterone system
Atrial fibrillation (AF) is one of the most common heart rhythm disorders. AF worsens the quality of life of patients and increases the risk of fatal cardiovascular complications. Obesity is a worldwide epidemic which prevalence has doubled in the past 30 years. The role of obesity as one of the predisposing factors for AF is currently being discussed. The modern literature describes several mechanisms of the influence of overweight on the development of arrhythmias: activation of the sympatho-adrenal nervous system, increased activity of the reninangiotensin- aldosterone system, development of arterial hypertension, insulin resistance, and lipid metabolism. Despite the large number of studies in this area, the pathogenesis of the development and progression of AF in obesity is not fully understood. The molecular mechanisms of AF development in obese patients include the occurrence of systemic inflammation. The most significant inflammatory activity is observed in the epicardial adipos