Аннотация:
Albumin nanovectors represent one of the most promising carriers recently generated because of the cost-effectiveness of their fabrication, biocompatibility, safety, and versatility in delivering hydrophilic and hydrophobic therapeutics and diagnostic agents. In this review, we describe and discuss the recent advances in how this technology has been harnessed for drug delivery in cancer, evaluating the commonly used synthesis protocols and considering the key factors that determine the biological transport and the effectiveness of such technology. With this in mind, we highlight how clinical and experimental albumin-based delivery nanoplatforms may be designed for tackling tumor progression or improving the currently established diagnostic procedures. © 2019 by the authors.
Ключевые слова:
Albumin; Cancer; Drug delivery; Nanomedicine
albumin; albumin nanovector; bevacizumab; carboplatin; cetuximab; cremophor; cyclophosphamide; drug carrier; epirubicin; fluorouracil; gemcitabine; immunoglobulin G; irinotecan; nanocarrier; nanoparticle; paclitaxel; pazopanib; rapamycin; reactive oxygen metabolite; sargramostim; small interfering RNA; temozolomide; unclassified drug; Article; cancer inhibition; cancer screening; cancer therapy; cell cycle arrest; cell infiltration; drug delivery system; drug half life; endocytosis; genetic engineering; human; image analysis; malignant neoplasm; nanoencapsulation; nanofabrication; nanomedicine; oxidation reduction potential; oxidative stress; pH; phase 1 clinical trial (topic); phase 2 clinical trial (topic); prostatectomy; protein aggregation; protein interaction; protein purification; protein quaternary structure; protein unfolding; temperature; tumor cell; ubiquitination
Parodi A. Alessandro 1978-
Miao J.
Sund S. M. Surinder Mokhan 1969-
Rudzhin`ska M. Magdalena 1986-
Zamyatnin A. A. Andrej Aleksandrovich 1976-
Пароди А. Алессандро 1978-
Миао Й.
Сунд С. М. Суриндер Мохан 1969-
Руджиньска М. Магдалена 1986-
Замятнин А. А. Андрей Александрович 1976-
Albumin nanovectors in cancer therapy and imaging
Текст визуальный непосредственный
Biomolecules
Vol.9, Issue6 Num.218
2019
Статья
Albumin Cancer Drug delivery Nanomedicine
albumin albumin nanovector bevacizumab carboplatin cetuximab cremophor cyclophosphamide drug carrier epirubicin fluorouracil gemcitabine immunoglobulin G irinotecan nanocarrier nanoparticle paclitaxel pazopanib rapamycin reactive oxygen metabolite sargramostim small interfering RNA temozolomide unclassified drug Article cancer inhibition cancer screening cancer therapy cell cycle arrest cell infiltration drug delivery system drug half life endocytosis genetic engineering human image analysis malignant neoplasm nanoencapsulation nanofabrication nanomedicine oxidation reduction potential oxidative stress pH phase 1 clinical trial (topic) phase 2 clinical trial (topic) prostatectomy protein aggregation protein interaction protein purification protein quaternary structure protein unfolding temperature tumor cell ubiquitination
Albumin nanovectors represent one of the most promising carriers recently generated because of the cost-effectiveness of their fabrication, biocompatibility, safety, and versatility in delivering hydrophilic and hydrophobic therapeutics and diagnostic agents. In this review, we describe and discuss the recent advances in how this technology has been harnessed for drug delivery in cancer, evaluating the commonly used synthesis protocols and considering the key factors that determine the biological transport and the effectiveness of such technology. With this in mind, we highlight how clinical and experimental albumin-based delivery nanoplatforms may be designed for tackling tumor progression or improving the currently established diagnostic procedures. © 2019 by the authors.