YSRAEV600Emutation in papillary thyroid carcinoma. Clinical and methodological aspects
Румянцев П. О., Никифорович П. А., Полозников А. А., Абросимов Â. У., Саенко В. А., Рогунович Т. И., Будзин А. А., Поляков А. П., Каприн А. Д., Дедов И. И.
Вопросы онкологии
Т. 65, Вып. 1, С. 16-26
Опубликовано: 2019
Тип ресурса: Обзор
Аннотация:
Mutation BRAFV600E is highly specific for papillary thyroid carcinoma. It's detected in 40-70[%] of all papillary thyroid carcinoma cases. Moreover this mutation is noticed in anaplastic carcinoma in 40-50[%].This fact gives a chance to select patients and provide targeted therapy with multi-kinase inhibitors in cases of unresectable anaplastic carcinoma. The influence of BRAF V600E mutation for response to radioactive iodine therapy requires more evidence-based research. Existing methods for determining the BRAFV<OOE mutation have different accuracy, availability and cost. Other methodological aspects are also associated with the sample preparation of biological material, the quality of reagents, and the cross-validation of research results. In this review, on the basis of our own experience and literature data, the indications for determining the mutation of the BRAFV600E gene in clinical practice are refined, and a comprehensive comparative analysis of modern research methods has bee
Ключевые слова:
BRAFvmEmutation; Molecular diagnostics; Personalized medicine; Thyroid cancer
B Raf kinase; biologist; clinical practice; endocrinologist; gene mutation; human; medical research; oncologist; pathologist; radiologist; Review; thyroid papillary carcinoma
Язык текста: Русский
ISSN: 0507-3758
Румянцев П. О.
Никифорович П. А.
Полозников А. А.
Абросимов Â. У.
Саенко В. А.
Рогунович Т. И.
Будзин А. А.
Поляков А. П.
Каприн А. Д.
Дедов И. И. Иван Иванович 1941-
Rumyantsev P. O.
Nikiforovich P. A.
Poloznikov A. A.
Abrosimov Â. U.
Saenko V. A.
Rogunovich T. I.
Budzin A. A.
Polyakov A. P.
Kaprin A. D.
Dedov I. I. Ivan Ivanovich 1941-
YSRAEV600Emutation in papillary thyroid carcinoma. Clinical and methodological aspects
Текст визуальный непосредственный
Вопросы онкологии
Вопросы онкологии
Т. 65, Вып. 1 С. 16-26
2019
Обзор
BRAFvmEmutation Molecular diagnostics Personalized medicine Thyroid cancer
B Raf kinase biologist clinical practice endocrinologist gene mutation human medical research oncologist pathologist radiologist Review thyroid papillary carcinoma
Mutation BRAFV600E is highly specific for papillary thyroid carcinoma. It's detected in 40-70[%] of all papillary thyroid carcinoma cases. Moreover this mutation is noticed in anaplastic carcinoma in 40-50[%].This fact gives a chance to select patients and provide targeted therapy with multi-kinase inhibitors in cases of unresectable anaplastic carcinoma. The influence of BRAF V600E mutation for response to radioactive iodine therapy requires more evidence-based research. Existing methods for determining the BRAFV<OOE mutation have different accuracy, availability and cost. Other methodological aspects are also associated with the sample preparation of biological material, the quality of reagents, and the cross-validation of research results. In this review, on the basis of our own experience and literature data, the indications for determining the mutation of the BRAFV600E gene in clinical practice are refined, and a comprehensive comparative analysis of modern research methods has bee