Mortality of patients with rheumatoid arthritis requiring intensive care: a single-center retrospective study
Haviv-Yadid Y., Segal Y., Dagan A., Sharif K., Bragazzi N. L., Watad A., Amital H., Shenfel`d I. Yu., Shovman O.
Clinical Rheumatology
Vol.38, Issue11, P. 3015-3023
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s10067-019-04651-w
Аннотация:
Background: Patients with rheumatoid arthritis (RA) are at a high risk for life-threatening conditions requiring admission to the intensive care unit (ICU), but the data regarding the outcomes of these patients is limited. The present study investigated the clinical characteristics and outcomes of RA patients admitted to an ICU. Methods: This retrospective cohort study included RA patients admitted to the general ICU of the Sheba Medical Center during 2002–2018. The main outcome was 30-day mortality. Using Student’s t test, χ2, and multivariable analyses, we compared the demographic, clinical, and laboratory parameters of the survivors and the non-survivors. Figures with p value < 0.05 were considered statistically significant. Results: Forty-three RA patients were admitted to the ICU during the study period (mean age, 64.0 ± 13.1 years; 74.4[%] female). The leading causes of ICU admission were infection (72.1[%]), respiratory failure (72.1[%]), renal failure (60.5[%]), and septic shock (55
Ключевые слова:
Acute physiology and chronic health evaluation (APACHE) II score; Intensive care unit; Rheumatoid arthritis mortality; Sequential organ failure assessment (SOFA) score
abatacept; azathioprine; cyclophosphamide; disease modifying antirheumatic drug; hydroxychloroquine; hypertensive factor; immunoglobulin; leflunomide; methotrexate; rituximab; steroid; tumor necrosis factor inhibitor; adult; aged; APACHE; area under the curve; Article; clinical article; clinical outcome; controlled study; female; fungus; Gram negative bacterium; Gram positive bacterium; heart failure; hospital admission; human; infection; intensive care; intensive care unit; kidney failure; male; mortality; mortality rate; nonhuman; observational study; priority journal; respiratory failure; retrospective study; rheumatoid arthritis; septic shock; Sequential Organ Failure Assessment Score; survivor; epidemiology; Israel; middle aged; rheumatoid arthritis; very elderly; young adult; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Humans; Intensive Care Units; Israel; Male; Middle Aged; Retrospective Studies; Young Adult
Язык текста: Английский
ISSN: 1434-9949
Haviv-Yadid Y.
Segal Y.
Dagan A.
Sharif K.
Bragazzi N. L.
Watad A.
Amital H.
Shenfel`d I. Yu. Ieguda Yulius 1948-
Shovman O.
Хавив-Ядид Y.
Сегал Y.
Даган А.
Шариф К.
Брагаззи Н. Л.
Wатад А.
Амитал Х.
Шенфельд И. Ю. Иегуда Юлиус 1948-
Шовман О.
Mortality of patients with rheumatoid arthritis requiring intensive care: a single-center retrospective study
Текст визуальный непосредственный
Clinical Rheumatology
Springer-Verlag London Ltd
Vol.38, Issue11 P. 3015-3023
2019
Статья
Acute physiology and chronic health evaluation (APACHE) II score Intensive care unit Rheumatoid arthritis mortality Sequential organ failure assessment (SOFA) score
abatacept azathioprine cyclophosphamide disease modifying antirheumatic drug hydroxychloroquine hypertensive factor immunoglobulin leflunomide methotrexate rituximab steroid tumor necrosis factor inhibitor adult aged APACHE area under the curve Article clinical article clinical outcome controlled study female fungus Gram negative bacterium Gram positive bacterium heart failure hospital admission human infection intensive care intensive care unit kidney failure male mortality mortality rate nonhuman observational study priority journal respiratory failure retrospective study rheumatoid arthritis septic shock Sequential Organ Failure Assessment Score survivor epidemiology Israel middle aged rheumatoid arthritis very elderly young adult Adult Aged Aged, 80 and over Arthritis, Rheumatoid Female Humans Intensive Care Units Israel Male Middle Aged Retrospective Studies Young Adult
Background: Patients with rheumatoid arthritis (RA) are at a high risk for life-threatening conditions requiring admission to the intensive care unit (ICU), but the data regarding the outcomes of these patients is limited. The present study investigated the clinical characteristics and outcomes of RA patients admitted to an ICU. Methods: This retrospective cohort study included RA patients admitted to the general ICU of the Sheba Medical Center during 2002–2018. The main outcome was 30-day mortality. Using Student’s t test, χ2, and multivariable analyses, we compared the demographic, clinical, and laboratory parameters of the survivors and the non-survivors. Figures with p value < 0.05 were considered statistically significant. Results: Forty-three RA patients were admitted to the ICU during the study period (mean age, 64.0 ± 13.1 years; 74.4[%] female). The leading causes of ICU admission were infection (72.1[%]), respiratory failure (72.1[%]), renal failure (60.5[%]), and septic shock (55