Molecular mechanisms of aging: the role of oxidative stress and epigenetic modifications
Аитбаев К. А., Муркамилов И. Т., Фомин В. В.
Успехи геронтологии
Т. 32, Вып. 1-2, С. 20-28
Опубликовано: 2019
Тип ресурса: Обзор
Аннотация:
Aging is a multifactorial process characterized by the gradual loss of physiological functions, which leads to increased vulnerability of the organism to age-related diseases and, finally, to death. To explain the nature of aging, several theories have been proposed, one of which relates aging to damage to cell structures and DNA caused by free radicals. However, an increasing amount of evidence suggests that molecular mechanisms of aging are also associated with epigenetic modifications, such as DNA methylation, non-coding RNA and histone changes. In this review, we will analyze the significance of the results of these studies and show how the interrelated effects of oxidative stress and epigenetics can explain the cause of the extinction of physiological functions during aging.Старение — это многофакторный процесс, характеризующийся постепенной потерей физиологических функций, что приводит к повышению уязвимости организма к возрастным заболеваниям и, наконец, к смерти. Для объяснения
Ключевые слова:
aging; epigenetic modifications; molecular mechanisms; oxidative stress; reactive oxygen species
histone; aging; DNA methylation; genetic epigenesis; human; oxidative stress; Aging; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Oxidative Stress
Язык текста: Русский
ISSN: 1561-9125
Аитбаев К. А.
Муркамилов И. Т.
Фомин В. В. Виктор Викторович 1978-
Aitbaev K. A.
Murkamilov I. T.
Fomin V. V. Viktor Viktorovich 1978-
Molecular mechanisms of aging: the role of oxidative stress and epigenetic modifications
Текст визуальный непосредственный
Успехи геронтологии
ООО "Эскулап"
Т. 32, Вып. 1-2 С. 20-28
2019
Обзор
aging epigenetic modifications molecular mechanisms oxidative stress reactive oxygen species
histone aging DNA methylation genetic epigenesis human oxidative stress Aging DNA Methylation Epigenesis, Genetic Histones Humans Oxidative Stress
Aging is a multifactorial process characterized by the gradual loss of physiological functions, which leads to increased vulnerability of the organism to age-related diseases and, finally, to death. To explain the nature of aging, several theories have been proposed, one of which relates aging to damage to cell structures and DNA caused by free radicals. However, an increasing amount of evidence suggests that molecular mechanisms of aging are also associated with epigenetic modifications, such as DNA methylation, non-coding RNA and histone changes. In this review, we will analyze the significance of the results of these studies and show how the interrelated effects of oxidative stress and epigenetics can explain the cause of the extinction of physiological functions during aging.Старение — это многофакторный процесс, характеризующийся постепенной потерей физиологических функций, что приводит к повышению уязвимости организма к возрастным заболеваниям и, наконец, к смерти. Для объяснения